PARTIAL SYNTHESIS OF MAJOR HUMAN METABOLITES OF DOCETAXEL

被引：16

作者：

COMMERCON, A

BOURZAT, JD

BEZARD, D

VUILHORGNE, M

机构：

[1] Rhône-Poulenc Rorer S.A.- Centre de Recherches de Vitry-Alfortville 13, 94403 Vitry-sur-Seine

来源：

TETRAHEDRON | 1994年 / 50卷 / 34期

关键词：

D O I：

10.1016/S0040-4020(01)81761-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structures and synthesis of the four major human metabolites of docetaxel are reported. These metabolites, i.e. compounds 3, 4a,b and 5, are side-chain oxidation derivatives. They were prepared by partial synthesis from the previously described amino-taxoid 8 using mixed-carbonates as acylation reagents. In vitro biological activities are detailed.

引用

页码：10289 / 10298

页数：10

共 26 条

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[2]

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[3]

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[4]

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