GELATIN COACERVATE MICROCAPSULES CONTAINING SULPHAMERAZINE - THEIR PREPARATION AND IN VITRO RELEASE OF DRUG

被引：47

作者：

NIXON, JR

KHALIL, SAH

CARLESS, JE

机构：

[1] Department of Pharmacy, Chelsea College of Science and Technology. (University of London), London, SW3, Manresa Road

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09801.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An improved method is described for the preparation of gelatin coacervate microcapsules containing sulphamerazine as a fine deflocculated powder. The factors which control both the coacervation step and the recovery of the microcapsules are discussed. The in vitro release of sulphamerazine from microcapsules of different wall thickness which had been hardened by formaldehyde under different conditions has been studied. The method of preparation gave a high percentage of encapsulated material in comparison with other recovery techniques. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：528 / &

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