GELATIN COACERVATE MICROCAPSULES CONTAINING SULPHAMERAZINE - THEIR PREPARATION AND IN VITRO RELEASE OF DRUG

被引：47

作者：

NIXON, JR

KHALIL, SAH

CARLESS, JE

机构：

[1] Department of Pharmacy, Chelsea College of Science and Technology. (University of London), London, SW3, Manresa Road

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 07期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09801.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An improved method is described for the preparation of gelatin coacervate microcapsules containing sulphamerazine as a fine deflocculated powder. The factors which control both the coacervation step and the recovery of the microcapsules are discussed. The in vitro release of sulphamerazine from microcapsules of different wall thickness which had been hardened by formaldehyde under different conditions has been studied. The method of preparation gave a high percentage of encapsulated material in comparison with other recovery techniques. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：528 / &

共 21 条

[11] ROLE OF PH IN COACERVATION OF SYSTEMS - GELATIN-WATER-ETHANOL AND GELATIN-WATER-SODIUM SULPHATE [J].

KHALIL, SAH ;

NIXON, JR ;

CARLESS, JE .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1968, 20 (03) :215-&

[12] EFFECTS OF SELECTED VARIABLES ON MICROENCAPSULATION OF SOLIDS [J].

LUZZI, LA ;

GERRAUGH.RJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (05) :634-&

[13] EFFECTS OF SELECTED VARIABLES ON EXTRACTABILITY OF OILS FROM COACERVATE CAPSULES [J].

LUZZI, LA ;

GERRAUGHTY, RJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :429-&

[14] EFFECT OF ADDITIVES AND FORMULATION TECHNIQUES ON CONTROLLED RELEASE OF DRUGS FROM MICROCAPSULES [J].

LUZZI, LA ;

GERRAUGH.RJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (09) :1174-&

[15]

Maier K., 1960, KOLLOID Z, V171, P122

[16] PHASE RELATIONSHIPS IN SIMPLE COACERVATING SYSTEM ISOELECTRIC GELATIN - ETHANOL - WATER [J].

NIXON, JR ;

KHALIL, SAH ;

CARLESS, JE .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1966, 18 (07) :409-&

[17] COATING PHARMACEUTICALS BY COACERVATION [J].

PHARES, RE ;

SPERANDIO, GJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (05) :515-&

[18]

Schleicher L. B., 1956, US Patent, Patent No. [2,730,456, 2730456]

[19]

SOUDER JC, 1958, DRUG STAND, V26, P77

[20] A NEW ORAL GELATINIZED SUSTAINED-RELEASE DOSAGE FORM [J].

TANAKA, N ;

UTSUMI, I ;

TAKINO, S .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (07) :664-&

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