STRUCTURE OF THE HUMAN BETA-GLOBIN GENE IN BETA-THALASSEMIA

被引：79

作者：

FLAVELL, RA ^{[1
]}

BERNARDS, R ^{[1
]}

KOOTER, JM ^{[1
]}

BOER, E ^{[1
]}

LITTLE, PFR ^{[1
]}

ANNISON, G ^{[1
]}

WILLIAMSON, R ^{[1
]}

机构：

[1] UNIV LONDON, ST MARYS HOSP MED SCH, DEPT BIOCHEM, LONDON, ENGLAND

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1093/nar/6.8.2749

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty-one cases of β0- and β+ -thalassaemia have been analysed by restriction endonuclease mapping. In most cases no deletion in the regions surrounding the β- and δ-globin genes could be detected. However, in a single Asian case of β0-thalassaemia, homozygous clinically, one of the homologous chromosomes contained a β-globin gene with a deletion of 600 base pairs of DNA and comprising most or all of the 3′ end of the structural gene including the EcoRI restriction site within the β-globin coding sequence. © 1979 Information Retrieval Limited.

引用

页码：2749 / 2760

页数：12