CHROMOSOMAL LOCALIZATION OF 7 MEMBERS OF THE MURINE TGF-BETA SUPERFAMILY SUGGESTS CLOSE LINKAGE TO SEVERAL MORPHOGENETIC MUTANT LOCI

被引：130

作者：

DICKINSON, ME

KOBRIN, MS

SILAN, CM

KINGSLEY, DM

JUSTICE, MJ

MILLER, DA

CECI, JD

LOCK, LF

LEE, A

BUCHBERG, AM

SIRACUSA, LD

LYONS, KM

DERYNCK, R

HOGAN, BLM

COPELAND, NG

JENKINS, NA

机构：

[1] VANDERBILT UNIV, MED CTR, SCH MED, DEPT CELL BIOL, NASHVILLE, TN 37232 USA

[2] GENENTECH INC, DEPT DEV BIOL, S SAN FRANCISCO, CA 94080 USA

[3] NCI, FREDERICK CANC RES FACIL,BIONET RES INC, BASIC RES PROGRAM,MAMMALIAN GENET LAB, FREDERICK, MD 21701 USA

[4] GENENTECH INC, DEPT MOLEC BIOL, S SAN FRANCISCO, CA 94080 USA

来源：

GENOMICS | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1016/0888-7543(90)90480-I

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chromosomal locations have been assigned to seven members of the TGF-β superfamily using an interspecific mouse backcross. Probes for the Tgfb-1, -2, and -3, Bmp-2a and -3, and Vgr-1 genes recognized only single loci, whereas the Bmp-2b probe recognized two independently segregating loci (designated Bmp-2b1 and Bmp-2b2). The results show that the seven members of the TGF-β superfamily map to eight different chromosomes, indicating that the TGF-β family has become widely dispersed during evolution. Five of the eight loci (Tgfb-1, Bmp-2a, Bmp-2b1, Bmp-2b2, Vgr-1) mapped near mutant loci associated with connective tissue and skeletal disorders, raising the possibility that at least some of these mutations result from defects in TGF-β-related genes. © 1990.

引用

页码：505 / 520

页数：16

共 72 条

[61] TRANSFORMING GROWTH FACTOR-BETA INCREASES MESSENGER-RNA FOR MATRIX PROTEINS BOTH IN THE PRESENCE AND IN THE ABSENCE OF CHANGES IN MESSENGER-RNA STABILITY [J].