MODIFICATION OF RADIATION RESPONSE OF CHO CELLS BY METHYL-ISOBUTYL XANTHINE .1. REDUCTION OF DO

被引:10
作者
LEHNERT, S
机构
关键词
D O I
10.2307/3575002
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Methyl-isobutyl xanthine (MIX), an inhibitor of cyclic AMP phosphodiesterase, induces transient elevation of intracellular cyclic AMP in CHO cells when added to the medium. Reduction of D(o) of irradiated, exponentially growing CHO cells is observed when MIX is added to the medium shortly before or shortly after irradiation, or when dibutyryl cyclic AMP or prostaglandin E1 are added after irradiation. Results of the latter experiment and of experiments in which the time of MIX addition was varied in relation to the time of irradiation suggested that an important factor in reducing D(o) in MIX-treated irradiated cells was the presence of an elevated concentration of intracellular cyclic AMP after irradiation. MIX-treated cells showed reduction in survival when irradiated with high doses in late G1 and S phase, but no reduction when irradiated in early G1.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 24 条
[11]   MODIFICATION OF POSTIRRADIATION SURVIVAL OF MAMMALIAN-CELLS BY INTRACELLULAR CYCLIC-AMP [J].
LEHNERT, S .
RADIATION RESEARCH, 1975, 62 (01) :107-116
[12]   REPAIR OF SUB-LETHAL AND POTENTIALLY LETHAL RADIATION DAMAGE IN PLATEAU PHASE CULTURES OF HUMAN CELLS [J].
LITTLE, JB .
NATURE, 1969, 224 (5221) :804-&
[13]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[14]  
Peterson D. F., 1968, Methods Cell Physiol, V3, P347
[15]   CATECHOL-ORTHO-METHYL-TRANSFERASE ACTIVITY IN DIBUTYRYL CYCLIC AMP, PROSTAGLANDIN AND X-RAY-INDUCED DIFFERENTIATED NEUROBLASTOMA CELL-CULTURE [J].
PRASAD, KN ;
MANDAL, B .
EXPERIMENTAL CELL RESEARCH, 1972, 74 (02) :532-&
[16]  
REMINGTON JA, 1973, BIOCHEM BIOPH RES CO, V50, P141
[17]   X-RAY AND ULTRAVIOLET SENSITIVITY OF SYNCHRONIZED CHINESE HAMSTER CELLS AT VARIOUS STAGES OF CELL CYCLE [J].
SINCLAIR, WK ;
MORTON, RA .
BIOPHYSICAL JOURNAL, 1965, 5 (01) :1-&
[18]   EFFECT OF THEOPHYLLINE AND CERTAIN OTHER PURINE DERIVATIVES ON TYROSINE AMINOTRANSFERASE ACTIVITY IN HEPATOMA-CELLS IN CULTURE [J].
STELLWAGEN, RH .
BIOCHIMICA ET BIOPHYSICA ACTA, 1974, 338 (02) :428-439
[19]  
THOMAS DB, 1973, J CEL BIOL, V57, P395
[20]  
THOMPSON LH, 1968, INT J RADIAT BIOL, V15, P181