THE HUMAN APO-1 (APT) ANTIGEN MAPS TO 10Q23, A REGION THAT IS SYNTENIC WITH MOUSE CHROMOSOME-19

被引：51

作者：

LICHTER, P ^{[1
]}

WALCZAK, H ^{[1
]}

WEITZ, S ^{[1
]}

BEHRMANN, I ^{[1
]}

KRAMMER, PH ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM FORSCHUNGSSWERPUNKT TUMORIMMUNOL,W-6900 HEIDELBERG,GERMANY

来源：

GENOMICS | 1992年 / 14卷 / 01期

关键词：

D O I：

10.1016/S0888-7543(05)80302-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The APO-1 (APT) antigen is a cell surface antigen expressed on a variety of normal and malignant cells. Binding of anti-APO-1 antibody to the APO-1 antigen induces programmed cell death (apoptosis). The APO-1 antigen shows homology to the members of the tumor necrosis factor receptor/nerve growth factor receptor superfamily. Using cosmid DNA containing the APO-1 gene as a probe for fluorescence in situ hybridization, we have mapped the gene to a subregion of chromosomal band 10q23. The human APO-1 locus lies within a conserved synteny segment present on mouse chromosome 19 consistent with the previous chromosomal assignment of the corresponding mouse antigen. © 1992 Academic Press, Inc. All rights reserved.

引用

页码：179 / 180

页数：2

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