THE INVOLVEMENT OF AN O-2-DERIVED NUCLEOPHILIC SPECIES IN ACYL-CARBON CLEAVAGE, CATALYZED BY CYTOCHROME P-450(17-ALPHA) - IMPLICATIONS FOR RELATED P-450 CATALYZED FRAGMENTATION REACTIONS

被引：17

作者：

ROBICHAUD, P ^{[1
]}

WRIGHT, JN ^{[1
]}

AKHTAR, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,DEPT BIOCHEM,SOUTHAMPTON SO16 7PX,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 12期

关键词：

D O I：

10.1039/c39940001501

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The postulated iron peroxy species involved in acyl-carbon fission by 17 alpha-hydroxylase-17,20-lyase (P-450(17 alpha)) was trapped by an aldehyde analogue, partial 9, that was cleaved by the enzyme 10 times faster than the side-chain of the natural substrate 1.

引用

页码：1501 / 1503

页数：3

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