THE MECHANISM OF CYTOCHROME-P-450 DEPENDENT C-C BOND-CLEAVAGE - STUDIES ON 17-ALPHA-HYDROXYLASE-17,20-LYASE

被引：37

作者：

CORINA, DL ^{[1
]}

MILLER, SL ^{[1
]}

WRIGHT, JN ^{[1
]}

AKHTAR, M ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,SCH BIOL SCI,DEPT BIOCHEM,SOUTHAMPTON SO9 3TU,HANTS,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 11期

关键词：

D O I：

10.1039/c39910000782

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It is shown that formation of 17-alpha-hydroxyandrost-5-en-3-beta-ol from pregnenolone occurs solely at the expense of the cleavage of the C-17-C-20 bond of the precursor and is best rationalised by invoking the participation of an Fe(III)-OOH intermediate in the acyl-carbon fission process.

引用

页码：782 / 783

页数：2

共 14 条

[1] STUDIES ON REMOVAL OF C-19 IN ESTROGEN BIOSYNTHESIS USING (O2)-O-18 [J].

AKHTAR, M ;

CORINA, D ;

PRATT, J ;

SMITH, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1976, (21) :854-856

[2] CHEMICAL AND ENZYMIC STUDIES ON CHARACTERIZATION OF INTERMEDIATES DURING REMOVAL OF 14-ALPHA-METHYL GROUP IN CHOLESTEROL-BIOSYNTHESIS - USE OF 32-FUNCTIONALIZED LANOSTANE DERIVATIVES [J].

AKHTAR, M ;

ALEXANDER, K ;

BOAR, RB ;

MCGHIE, JF ;

BARTON, DHR .

BIOCHEMICAL JOURNAL, 1978, 169 (03) :449-463

[3]

KOHARA H, 1987, BIOCHIM BIOPHYS ACTA, V921, P90

[4]

LYNN WS, 1958, J BIOL CHEM, V232, P1015

[5]

McMurry T. J., 1986, CYTOCHROME P450 STRU, P1

[6] MECHANISTIC STUDIES ON PREGNENE SIDE-CHAIN CLEAVAGE ENZYME (17-ALPHA-HYDROXYLASE-17,20-LYASE) USING O-18 [J].

MILLER, SL ;

WRIGHT, JN ;

CORINA, DL ;

AKHTAR, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (03) :157-159

[7] CYTOCHROME B5 PROMOTES THE SYNTHESIS OF DELTA-16-C-19 STEROIDS BY HOMOGENEOUS CYTOCHROME-P-450 C-21 SIDE-CHAIN CLEAVAGE FROM PIG TESTIS [J].

NAKAJIN, S ;

TAKAHASHI, M ;

SHINODA, M ;

HALL, PF .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 132 (02) :708-713

[8]

Ortiz de Montellano P. R., 1986, CYTOCHROME P450 STRU

[9] STEROID METABOLISM IN TESTIS TISSUE - CONCENTRATIONS OF UNCONJUGATED AND SULFATED NEUTRAL STEROIDS IN BOAR TESTIS [J].

RUOKONEN, A ;

VIHKO, R .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1974, 5 (01) :33-38

[10]

SHIMIZU K, 1978, J BIOL CHEM, V253, P4237

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