INCREASE IN EXOGENOUS CHOLINE FAILS TO ELEVATE THE CONTENT OR TURNOVER RATE OF CORTICAL, STRIATAL, OR HIPPOCAMPAL ACETYLCHOLINE

被引：26

作者：

BRUNELLO, N ^{[1
]}

CHENEY, DL ^{[1
]}

COSTA, E ^{[1
]}

机构：

[1] ST ELIZABETHS HOSP, NIMH, PRECLIN PHARMACOL LAB, WASHINGTON, DC 20032 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1982年 / 38卷 / 04期

关键词：

D O I：

10.1111/j.1471-4159.1982.tb05364.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The availability of choline was increased in rat brain to test whether increases in the rate of acetylcholine [ACh] synthesis occurred in that organ. The content of choline and ACh and the turnover rate of ACh in striatum, hippocampus and cerebral cortex were measured following changes in dietary choline, i.p. choline or i.v. infusion of choline. Increasing plasma choline caused some increase in tissue choline but did not increase ACh levels nor turnover rate in any of the areas of brain studied. In hippocampus, choline decreased the turnover rate of ACh.

引用

页码：1160 / 1163

页数：4