SPATIAL-DISTRIBUTION OF ENDOGENOUS RETINOIDS IN THE MURINE EMBRYONIC MANDIBLE

被引：12

作者：

KRONMILLER, JE ^{[1
]}

BEEMAN, CS ^{[1
]}

机构：

[1] UNIV KENTUCKY, COLL DENT, DEPT ORAL HLTH PRACTICE, LEXINGTON, KY USA

来源：

ARCHIVES OF ORAL BIOLOGY | 1994年 / 39卷 / 12期

关键词：

ENDOGENOUS RETINOIDS; CONCENTRATION GRADIENT; SPATIAL DISTRIBUTION; MANDIBLE; EMBRYONIC;

D O I：

10.1016/0003-9969(94)90060-4

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Retinoids play an important part in pattern formation during embryonic development. Exogenous retinoids alter the pattern of skeletal, neural and odontogenic tissues. Endogenous retinoids have been demonstrated previously in the murine embryonic mandible, reaching a concentration peak during the initiation of odontogenesis. It was now found that endogenous retinoids are present in a concentration gradient in the embryonic mouse mandible at the time of the initiation of the dental lamina. All-trans-retinoic acid was more concentrated in the incisor region and retinol in the molar region. These results, and the fact that exogenous retinoids produce supernumerary incisors and missing molars, suggest that all-trans-retinoic acid may instruct incisor morphology.

引用

页码：1071 / 1078

页数：8

共 66 条

[1] EGF RECEPTOR EXPRESSION IN THE DEVELOPING TOOTH IS ALTERED BY EXOGENOUS RETINOIC ACID AND EGF [J].

ABBOTT, BD ;

PRATT, RM .

DEVELOPMENTAL BIOLOGY, 1988, 128 (02) :300-304

[2]

ABBOTT BD, 1988, DEVELOPMENT, V102, P853

[3] RETINOIC ACID-INDUCED ALTERATIONS IN THE EXPRESSION OF GROWTH-FACTORS IN EMBRYONIC MOUSE PALATAL SHELVES [J].

ABBOTT, BD ;

BIRNBAUM, LS .

TERATOLOGY, 1990, 42 (06) :597-610

[4] RETINOIC ACID IMPROVES EPIDERMAL MORPHOGENESIS [J].

ASSELINEAU, D ;

BERNARD, BA ;

BAILLY, C ;

DARMON, M .

DEVELOPMENTAL BIOLOGY, 1989, 133 (02) :322-335

[5] TEMPORAL DISTRIBUTION OF ENDOGENOUS RETINOIDS IN THE EMBRYONIC MOUSE MANDIBLE [J].

BEEMAN, CS ;

KRONMILLER, JE .

ARCHIVES OF ORAL BIOLOGY, 1994, 39 (09) :733-739

[6]

BONCINELLI E, 1992, RETINOIDS NORMAL DEV, P213

[7]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[8] INTRACELLULAR SIGNALING BY 14-HYDROXY-4,14-RETRO-RETINOL [J].

BUCK, J ;

DERGUINI, F ;

LEVI, E ;

NAKANISHI, K ;

HAMMERLING, U .

SCIENCE, 1991, 254 (5038) :1654-1656

[9] SPECIFIC TRANSFORMING GROWTH-FACTOR-BETA SUBTYPES REGULATE EMBRYONIC MOUSE MECKELS CARTILAGE AND TOOTH DEVELOPMENT [J].

CHAI, Y ;

MAH, A ;

CROHIN, C ;

GROFF, S ;

BRINGAS, P ;

LE, T ;

SANTOS, V ;

SLAVKIN, HC .

DEVELOPMENTAL BIOLOGY, 1994, 162 (01) :85-103

[10] A CONCENTRATION GRADIENT OF RETINOIDS IN THE EARLY XENOPUS-LAEVIS EMBRYO [J].

CHEN, YP ;

HUANG, L ;

SOLURSH, M .

DEVELOPMENTAL BIOLOGY, 1994, 161 (01) :70-76

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