HETEROCYCLES IN ORGANIC-SYNTHESIS .6. NUCLEOPHILIC DISPLACEMENTS OF PRIMARY AMINO-GROUPS VIA 2,4,6-TRIPHENYLPYRIDINIUM SALTS

被引：48

作者：

KATRITZKY, AR

BAPAT, JB

BLADE, RJ

LEDDY, BP

NIE, PL

RAMSDEN, CA

THIND, SS

机构：

[1] School of Chemical Sciences, University of East Anglia

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 02期

关键词：

D O I：

10.1039/p19790000418

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzylamine and 2-, 3-, and 4-pyridylmethylamine are readily converted into the corresponding 1-substituted 2,4,6-triphenylpyridinium cations, from which 2,4,6-triphenylpyridine is displaced in high yield by a variety of nucleophiles. This synthetic method avoids the use of unstable and obnoxious pyridylmethyl halides and shows steric selectivity of significance in the conversion of secondary into tertiary amines by alkylation.

引用

页码：418 / 425

页数：8