EXPRESSION OF MALIGNANCY IN HYBRIDS BETWEEN NORMAL AND MALIGNANT-CELLS

被引：33

作者：

CROCE, CM

BARRICK, J

LINNENBACH, A

KOPROWSKI, H

机构：

[1] Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, 19104

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1979年 / 99卷 / 03期

关键词：

D O I：

10.1002/jcp.1040990302

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Somatic cell hybrids between either normal human fibroblasts, phenotypically normal mouse fibroblasts or mouse peritoneal macrophages and HT1080 human diploid fibrosarcoma cells were studied for their ability to form tumors in nude mice. The results of this study indicate that tumorigenic behavior is expressed as a dominant trait in both human‐human and mouse‐human hybrid cells. Copyright © 1979 Wiley‐Liss, Inc.

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页码：279 / 285

页数：7

相关论文

共 21 条

[1] TRANSFER OF GENE FOR THYMIDINE KINASE TO THYMIDINE KINASE-DEFICIENT HUMAN CELLS BY PURIFIED HERPES-SIMPLEX VIRAL-DNA [J].

BACCHETTI, S ;

GRAHAM, FL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (04) :1590-1594

[2] ASSIGNMENT OF GENE FOR CYTOPLASMIC GLUTAMIC-OXALOACETIC TRANSAMINASE TO REGION Q24-QTER OF HUMAN CHROMOSOME-10 [J].

CHERN, CJ ;

MELLMAN, WJ ;

CROCE, CM .

SOMATIC CELL GENETICS, 1976, 2 (02) :177-182

[3]

CHERN CJ, 1976, AM J HUM GENET, V28, P667

[4] SOMATIC-CELL HYBRIDS BETWEEN MOUSE PERITONEAL MACROPHAGES AND SIMIAN-VIRUS-40 TRANSFORMED HUMAN CELLS .2. PRESENCE OF HUMAN CHROMOSOME-7 CARRYING SIMIAN VIRUS-40 GENOME IN CELLS OF TUMORS INDUCED BY HYBRID CELLS [J].

CROCE, CM ;

ADEN, D ;

KOPROWSKI, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (04) :1397-1400

[5] LOSS OF MOUSE CHROMOSOMES IN SOMATIC-CELL HYBRIDS BETWEEN HT-1080 HUMAN FIBROSARCOMA CELLS AND MOUSE PERITONEAL MACROPHAGES [J].

CROCE, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (09) :3248-3252

[6] EFFECT OF ENVIRONMENTAL PARA H ON EFFICIENCY OF CELLULAR HYBRIDIZATION [J].

CROCE, CM ;

KOPROWSKI, H ;

EAGLE, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (07) :1953-+

[7] PREFERENTIAL RETENTION OF HUMAN CHROMOSOME C-7 IN HUMAN-(THYMIDINE KINASE DEFICIENT) MOUSE HYBRID CELLS [J].

CROCE, CM ;

KNOWLES, BB ;

KOPROWSKI, H .

EXPERIMENTAL CELL RESEARCH, 1973, 82 (02) :457-461

[8] TUMORIGENICITY OF MOUSE-HUMAN DIPLOID HYBRIDS IN NUDE MICE [J].

CROCE, CM ;

ADEN, D ;

KOPROWSKI, H .

SCIENCE, 1975, 190 (4220) :1200-1202

[9] GENETICS OF HUMAN CANCER [J].

CROCE, CM ;

KOPROWSKI, H .

SCIENTIFIC AMERICAN, 1978, 238 (02) :117-125

[10] SUPPRESSION OF MALIGNANCY BY CELL FUSION [J].

HARRIS, H ;

MILLER, OJ ;

KLEIN, G ;

WORST, P ;

TACHIBANA, T .

NATURE, 1969, 223 (5204) :363-+