ESOPHAGEAL DEFENSE-MECHANISMS

被引：6

作者：

HOPWOOD, D

机构：

来源：

DIGESTION | 1995年 / 56卷

关键词：

ESOPHAGUS; EPIDERMAL GROWTH FACTOR RECEPTOR; CAMS; BARRIER;

D O I：

10.1159/000201294

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Various defence mechanisms are found in the oesophagus which can be elicited by reflux damage. Premucosal defence includes bicarbonate ions and epidermal growth factor (EGF) secreted by salivary and oesophageal glands. The mucosa can respond by increasing epithelial cell turnover and upregulating EGF receptor and endocytosis. The intercellular barrier can be increased by the contents of membrane-coating granules. Local pH can be regulated by carbonic anhydrase. The whole viscus can exhibit peristalsis to effect a mechanical clearance of the refluxed gastric and duodenal material.

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页码：5 / 8

页数：4

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