2-ACETYLPYRIDINE THIOSEMICARBAZONES .1. NEW CLASS OF POTENTIAL ANTI-MALARIAL AGENTS

被引：485

作者：

KLAYMAN, DL

BARTOSEVICH, JF

GRIFFIN, TS

MASON, CJ

SCOVILL, JP

机构：

[1] Walter Reed Army Institute of Research, Division of Experimental Therapeutics, Washington

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 07期

关键词：

D O I：

10.1021/jm00193a020

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity. © 1979, American Chemical Society. All rights reserved.

引用

页码：855 / 862

页数：8

共 39 条

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