A NEW HIGH-YIELD SEMISYNTHETIC APPROACH TO (20S)-9-NH2-CAMPTOTHECIN BASED ON A SEQUENCE OF PALLADIUM-CATALYZED REDUCTIONS

被引：13

作者：

CABRI, W ^{[1
]}

CANDIANI, I ^{[1
]}

ZARINI, F ^{[1
]}

PENCO, S ^{[1
]}

BEDESCHI, A ^{[1
]}

机构：

[1] PHARMACIA,PROC RES,I-20014 NERVIANO,ITALY

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 50期

关键词：

D O I：

10.1016/0040-4039(95)01939-F

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new 5-step synthesis of 9-NH2-Camptothecin starting from naturalCamptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.

引用

页码：9197 / 9200

页数：4

共 19 条

[11] POTMESIL M, 1993, MOL BIOL DNA TOPOISO, pCH29
[12] SAWADA S, 1991, CHEM PHARM BULL, V39, P3183
[13] SAWADA S, 1984, Patent No. 160945
[14] SAWADA S, 1984, Patent No. 160944
[15] Shen Wang, 1993, Journal of Organic Chemistry, V58, P611, DOI 10.1021/jo00055a012
[16] THE CURRENT STATUS OF CAMPTOTHECIN ANALOGS AS ANTITUMOR AGENTS
SLICHENMYER, WJ
ROWINSKY, EK
DONEHOWER, RC
KAUFMANN, SH
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (04): : 271 - 291
[17] EFFECTS OF CAMPTOTHECIN ON MAMMALIAN DNA
SPATARO, A
KESSEL, D
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 331 (02) : 194 - 201
[18] PLANT ANTITUMOR AGENTS .I. ISOLATION AND STRUCTURE OF CAMPTOTHECIN A NOVEL ALKALOIDAL LEUKEMIA AND TUMOR INHIBITOR FROM CAMPTOTHECA ACUMINATA
WALL, ME
WANI, MC
COOK, CE
PALMER, KH
MCPHAIL, AT
SIM, GA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (16) : 3888 - 3890
[19] AN EFFICIENT CONVERSION OF CAMPTOTHECIN TO 10-HYDROXYCAMPTOTHECIN
WOOD, JL
FORTUNAK, JM
MASTROCOLA, AR
MELLINGER, M
BURK, PL
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (17) : 5739 - 5740

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