(+/-)-GELLIUSINE-A AND (+/-)-GELLIUSINE-B, 2 DIASTEREOMERIC BROMINATED TRIS-INDOLE ALKALOIDS FROM A DEEP-WATER NEW CALEDONIAN MARINE SPONGE (GELLIUS OR ORINA SP)

被引:66
作者
BIFULCO, G
BRUNO, I
MINALE, L
RICCIO, R
CALIGNANO, A
DEBITUS, C
机构
[1] UNIV NAPLES,DIPARTIMENTO CHIM SOSTANZE NAT,I-80131 NAPLES,ITALY
[2] UNIV NAPLES,DIPARTIMENTO FARMACOL SPERIMENTALE,I-80131 NAPLES,ITALY
来源
JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 09期
关键词
D O I
10.1021/np50111a020
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Two new diastereomeric brominated tris-indole alkaloids occurring as enantiomeric pairs, (+/-)-gelliusines A [1] and B [2], have been isolated from a deep water New Caledonian sponge (Gellius or Orina sp.), whose crude extract exhibited cytotoxicity against KB cells. Their structures were elucidated by spectroscopic methods including one- and two-dimensional nmr spectroscopy. The major compound, (+/-) gelliusine A [1], which showed very weak cytotoxicity, proved to be active at the serotonin receptor.
引用
收藏
页码:1294 / 1299
页数:6
相关论文
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