IDENTITY OF A BILIARY METABOLITE FORMED FROM MONOCROTALINE IN ISOLATED, PERFUSED-RAT-LIVER

被引：37

作者：

MATTOCKS, AR ^{[1
]}

CROSWELL, S ^{[1
]}

JUKES, R ^{[1
]}

HUXTABLE, RJ ^{[1
]}

机构：

[1] UNIV ARIZONA,HLTH SCI CTR,SCH MED,DEPT PHARMACOL,TUCSON,AZ 85724

来源：

TOXICON | 1991年 / 29卷 / 4-5期

关键词：

D O I：

10.1016/0041-0101(91)90015-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A pneumotoxic pyrrolic metabolite, previously isolated from the bile when rat liver was perfused with the pyrrolizidine alkaloid, monocrotaline, has been identified as 7-glutathionyl-dehydroretronecine. The metabolite showed a TLC spot and HPLC peak corresponding with the latter compound, and a procedure for replacing the thioether group with an ethoxy group converted the metabolite to dehydroretronecine 7-ethyl ether, confirming that the glutathionyl moiety was attached to the 7-position of dehydroretronecine. The same metabolite was detected in bile from rat liver perfused with retrorsine, which is a diester alkaloid similar to monocrotaline, whereas it was not formed from heliotrine, an alkaloid lacking the 7-ester function.

引用

页码：409 / 415

页数：7

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