SEROTONIN 1A-RECEPTOR ACTIVATION SUPPRESSES RESPIRATORY APNEUSIS IN THE CAT

被引：62

作者：

LALLEY, PM ^{[1
]}

BISCHOFF, AM ^{[1
]}

RICHTER, DW ^{[1
]}

机构：

[1] UNIV GOTTINGEN,INST PHYSIOL 2,D-37073 GOTTINGEN,GERMANY

来源：

NEUROSCIENCE LETTERS | 1994年 / 172卷 / 1-2期

关键词：

APNEUSIS; SEROTONIN 5-HT1A RECEPTOR; NMDA RECEPTOR; BARBITURATE; HYPOXIA;

D O I：

10.1016/0304-3940(94)90662-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Malfunction of inhibitory synaptic processes in the brainstem result in abnormal prolonged inspiration (apneusis). Since we previously found that the serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A receptor agonist 8-hydroxy-dipropylaminotetralin (8-OH-DPAT) shortens inspiratory discharges, we tested its ability to suppress apneusis. We recorded phrenic nerve activity and the membrane potential of medullary expiratory (E-2) and postinspiratory (PI) neurons in 14 anaesthetized, paralyzed, artifically ventilated cats. Systemic hypoxia or i.v. injection of pentobarbital sodium or the N-methyl-D-aspartate (NMDA) receptor blocker ketamine induced apneustic phrenic nerve discharges, delayed depolarization to threshold of E-2 neurons and prolonged hyperpolarization in PI neurons. 8-OH-DPAT (10-40 mu g/kg i.v.) produced partial to complete restoration of normal phrenic nerve discharges and membrane potential.

引用

页码：59 / 62

页数：4

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