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TRISOMY-11 AND OTHER NONRANDOM TRISOMIES IN CONGENITAL FIBROSARCOMA

被引：16
作者：
BERNSTEIN, R
ZELTZER, PM
LIN, F
CARPENTER, PM
机构：
[1] UNIV CALIF IRVINE,COLL MED,DIV HUMAN GENET,ORANGE,CA 92613
[2] UNIV CALIF IRVINE,COLL MED,DIV HEMATOL ONCOL,ORANGE,CA 92613
[3] UNIV CALIF IRVINE,COLL MED,DEPT PEDIAT,ORANGE,CA 92613
[4] UNIV CALIF IRVINE,COLL MED,DEPT PATHOL,ORANGE,CA 92613
来源：
CANCER GENETICS AND CYTOGENETICS | 1994年 / 78卷 / 01期
关键词：
D O I：
10.1016/0165-4608(94)90051-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chromosome studies in a 7-week-old female infant with an intraabdominal malignant fibrosarcoma showed a hyperdiploid karyotype of 50,XX, +der(6)del(6)(p23)add(6)(q11), +8, +10, +11,add(12)(p13). Trisomy 11 appears to be a nonrandom primary cytogenetic abnormality in the congenital or infantile form of this mesenchymal tumor and is also a nonrandom gain in congenital mesoblastic nephroma. A possible developmental link between these two mesenchymal tumors, mediated by a gene or genes on chromosome 11 is postulated.
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页码：82 / 86
页数：5
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