A SALMONELLA-TYPHIMURIUM VIRULENCE PROTEIN IS SIMILAR TO A YERSINIA-ENTEROCOLITICA INVASION PROTEIN AND A BACTERIOPHAGE-LAMBDA OUTER-MEMBRANE PROTEIN

被引：132

作者：

PULKKINEN, WS ^{[1
]}

MILLER, SI ^{[1
]}

机构：

[1] HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,INFECT DIS UNIT,BOSTON,MA 02114

来源：

JOURNAL OF BACTERIOLOGY | 1991年 / 173卷 / 01期

关键词：

D O I：

10.1128/jb.173.1.86-93.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The PhoP-PhoQ-regulated pagC locus is essential for full virulence and survival within macrophages of Salmonella typhimurium. The protein product, DNA sequence, and transcript of pagC were determined. The pagC locus encodes a single 188-amino-acid membrane protein that is similar to the ail-encoded eucaryotic cell invasion protein of Yersinia enterocolitica and the lom-encoded protein of bacteriophage lambda. The similarity of PagC and Ail to Lom leads us to hypothesize that Lom is a virulence protein and that bacteriophage gene transfer and lysogeny could have led to the development of proteins essential to survival within macrophages and eucaryotic cell invasion.

引用

页码：86 / 93

页数：8

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