Contributors of the Severity of Airflow Limitation in COPD Patients

被引：2

作者：

Hong, Yoonki ^{[1
]}

Chae, Eun Jin ^{[2
]}

Seo, Joon Beom ^{[2
]}

Lee, Ji-Hyun ^{[3
]}

Kim, Eun-Kyung ^{[3
]}

Lee, Young Kyung ^{[4
]}

Kim, Tae-Hyung ^{[5
]}

Kim, Woo Jin ^{[6
]}

Lee, Jin Hwa ^{[7
]}

Lee, Sang-Min ^{[8
]}

Lee, Sangyeub ^{[9
]}

Lim, Seong Yong ^{[10
]}

Shin, Tae Rim ^{[11
]}

Yoon, Ho Il ^{[12
]}

Sheen, Seung Soo ^{[13
]}

Ra, Seung Won ^{[14
]}

Lee, Jae Seung ^{[1
]}

Huh, Jin Won ^{[1
]}

Lee, Sang-Do ^{[1
]}

Oh, Yeon-Mok ^{[1
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pulm & Crit Care Med, 86 Asanbyeonwon Gil, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Asan Med Ctr, Clin Res Ctr Chron Obstruct Airway Dis, Seoul, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Radiol, Seoul, South Korea

[4] CHA Univ, Bundang CHA Hosp, Coll Med, Dept Internal Med,Div Pulm & Crit Care Med, Seongnam, South Korea

[5] Kyung Hee Univ, East West Neo Med Ctr, Sch Med, Dept Radiol, Seoul, South Korea

[6] Hanyang Univ, Guri Hosp, Coll Med, Dept Internal Med,Div Pulmonol, Guri, South Korea

[7] Kangwon Natl Univ, Coll Med, Dept Internal Med, Chunchon, South Korea

[8] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[9] Korea Univ, Anam Hosp, Coll Med, Dept Internal Med,Div Resp & Crit Care Med, Seoul, South Korea

[10] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Med,Div Pulm & Crit Care Med, Seoul, South Korea

[11] Hallym Univ, Kangnam Sacred Heart Hosp, Coll Med, Dept Internal Med, Seoul, South Korea

[12] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Seongnam, South Korea

[13] Ajou Univ, Sch Med, Dept Pulm & Crit Care Med, Suwon, South Korea

[14] Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Internal Med, Ulsan, South Korea

来源：

TUBERCULOSIS AND RESPIRATORY DISEASES | 2012年 / 72卷 / 01期

关键词：

Pulmonary Disease; Chronic Obstructive; Forced Expiratory Volumes; Tomography; X-Ray Computed;

D O I：

10.4046/trd.2012.72.1.8

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background: Although airway obstruction in chronic obstructive pulmonary disease (COPD) is due to pathologic processes in both the airways and the lung parenchyma, the contribution of these processes, as well as other factors, have not yet been evaluated quantitatively. We therefore quantitatively evaluated the factors contributing to airflow limitation in patients with COPD. Methods: The 213 COPD patients were aged >45 years, had smoked >10 pack-years of cigarettes, and had a post-bronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) <0.7. All patients were evaluated by medical interviews, physical examination, spirometry, bronchodilator reversibility tests, lung volume, and 6-minute walk tests. In addition, volumetric computed tomography (CT) was performed to evaluate airway wall thickness, emphysema severity, and mean lung density ratio at full expiration and inspiration. Multiple linear regression analysis was performed to identify the variables independently associated with FEV1 - the index of the severity of airflow limitation. Results: Multiple linear regression analysis showed that CT measurements of mean lung density ratio (standardized coefficient beta=-0.46; p<0.001), emphysema severity (volume fraction of the lung less than - 950 HU at full inspiration; beta=-0.24; p<0.001), and airway wall thickness (mean wall area %; beta=-0.19, p=0.001), as well as current smoking status (beta=-0.14; p=0.009) were independent contributors to FEV1. Conclusion: Mean lung density ratio, emphysema severity, and airway wall thickness evaluated by volumetric CT and smoking status could independently contribute to the severity of airflow limitation in patients with COPD.

引用

页码：8 / 14

页数：7

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