POLYCHLORINATED BIPHENYL LEVELS IN THE TISSUES OF EXPOSED AND NONEXPOSED HUMANS

被引:63
作者
SCHECTER, A
STANLEY, J
BOGGESS, K
MASUDA, Y
MES, J
WOLFF, M
FURST, P
FURST, C
WILSONYANG, K
CHISHOLM, B
机构
[1] MIDWEST RES INST,KANSAS CITY,MO 64110
[2] DAIICHI COLL PHARMACEUT SCI,MINANI KU,FUKUOKA 815,JAPAN
[3] HLTH & WELF CANADA,OTTAWA K1A 0L2,ON,CANADA
[4] CUNY MT SINAI SCH MED,DIV ENVIRONM & OCCUPAT MED,NEW YORK,NY 10029
[5] STATE LAB N RHINE WESTPHALIA FOOD PHARM & ENVIRON,W-4400 MUNSTER,GERMANY
[6] ECOLOG INT INC,ROCKWOOD N0B 2K0,ON,CANADA
关键词
D O I
10.1289/ehp.94102s1149
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Polychlorinated biphenyls (PCBs) are synthetic chemicals, manufactured in volume from about 1929 to the 1970s. Environmental contamination by PCBs has been documented in various substances, including human tissue. PCBs have been measured in human tissue by a variety of analytical methods. PCB levels have been reported as an approximation of total PCB content expressed in terms of a commercial mixture, by identification and quantification of chromatographic peaks, or by qualitative and quantitative characterization of specific congeners. Until recently, the coplanar mono-ortho- and di-ortho substituted PCBs, which are especially toxic and present in significant concentration in humans from industrial countries, had not been measured in human tissues. Examples of various types of commonly used analyses are presented in general population subjects and in persons who experienced special exposure. In this paper, the usefulness of PCB blood determinations following potential exposure is demonstrated, and their application in health studies is illustrated from a number of case studies. Coplanar PCB, mono-ortho-substituted and di-ortho-substituted PCB levels in human blood are presented and compared with polychlorinated dioxin (PCDD) and polychlorinated dibenzofuran (PCDF) levels in the U.S. population. Dioxin toxic equivalents for the two groups of chemicals are calculated and compared. It is found that mono-ortho-substituted and, to a lesser extent, coplaner PCBs, contribute substantially to dioxin toxic equivalents (TEq) in blood from U.S. adults. Because of substantial PCB contribution to dioxin toxic equivalents, total dioxinlike toxicity can only be determined if dioxins, dibenzofurans, and dioxinlike PCBs are measured. At the present time, PCBs may contribute more dioxinlike toxicity in human tissues than do dioxins and furans in human tissues from the general population in the United States, and probably for other industrialized countries as well.
引用
收藏
页码:149 / 158
页数:10
相关论文
共 29 条
  • [1] ANALYSIS OF POLYCHLORINATED-BIPHENYLS (PCB) BY GLASS-CAPILLARY GAS-CHROMATOGRAPHY - COMPOSITION OF TECHNICAL AROCLOR-PCB AND CLOPHEN-PCB MIXTURES
    BALLSCHMITER, K
    ZELL, M
    [J]. FRESENIUS ZEITSCHRIFT FUR ANALYTISCHE CHEMIE, 1980, 302 (01): : 20 - 31
  • [2] BRINKMAN UA, 1989, HALOGENATED BIPHENYL, V4, P3
  • [3] CANTLON JE, 1983, PCBS HUMAN ENV HAZAR, P5
  • [4] PRENATAL EXPOSURE TO POLYCHLORINATED-BIPHENYLS - EFFECTS ON BIRTH SIZE AND GESTATIONAL-AGE
    FEIN, GG
    JACOBSON, JL
    JACOBSON, SW
    SCHWARTZ, PM
    DOWLER, JK
    [J]. JOURNAL OF PEDIATRICS, 1984, 105 (02) : 315 - 320
  • [5] RELATIONSHIP BETWEEN THE CONSUMPTION OF TOXIC RICE OIL AND THE LONG-TERM CONCENTRATION OF POLYCHLORINATED-BIPHENYLS IN THE BLOOD OF YUSHO PATIENTS
    HAYABUCHI, H
    IKEDA, M
    YOSHIMURA, T
    MASUDA, Y
    [J]. FOOD AND COSMETICS TOXICOLOGY, 1981, 19 (01): : 53 - 55
  • [6] EFFECTS OF EXPOSURE TO PCBS AND RELATED-COMPOUNDS ON GROWTH AND ACTIVITY IN CHILDREN
    JACOBSON, JL
    JACOBSON, SW
    HUMPHREY, HEB
    [J]. NEUROTOXICOLOGY AND TERATOLOGY, 1990, 12 (04) : 319 - 326
  • [7] JACOBSON SW, 1983, PCBS HUMAN ENV HAZAR, P311
  • [8] POTENTIALLY HAZARDOUS RESIDUES OF NON-ORTHO CHLORINE SUBSTITUTED COPLANAR PCBS IN HUMAN ADIPOSE-TISSUE
    KANNAN, N
    TANABE, S
    TATSUKAWA, R
    [J]. ARCHIVES OF ENVIRONMENTAL HEALTH, 1988, 43 (01): : 11 - 14
  • [9] PCDDS, PCDFS, PCBS, COPLANAR PCBS AND ORGANOCHLORINATED PESTICIDES IN HUMAN ADIPOSE-TISSUE IN JAPAN
    KASHIMOTO, T
    TAKAYAMA, K
    MIMURA, M
    MIYATA, H
    MURAKAMI, Y
    MATSUMOTO, H
    [J]. CHEMOSPHERE, 1989, 19 (1-6) : 921 - 926
  • [10] MASUDA Y, 1984, AM J IND MED, V5, P31