HEREDITARY NONPOLYPOSIS COLORECTAL-CANCER AND COLONIC ADENOMAS - AGGRESSIVE ADENOMAS

被引：59

作者：

LYNCH, HT

SMYRK, T

JASS, JR

机构：

[1] Department of Preventive Medicine, Creighton University School of Medicine, Omaha, Nebraska

[2] Department of Pathology, Clarkson Hospital, Omaha, Nebraska

[3] Department of Pathology, University of Auckland School of Medicine, Auckland

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1995年 / 11卷 / 06期

关键词：

HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; COLONIC ADENOMAS; ACCELERATED PROGRESSION TO CANCER;

D O I：

10.1002/ssu.2980110607

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hereditary nonpolyposis colorectal cancer (HNPCC) results from an inherited defect in one of the genes responsible for repair of errors that occur during DNA replication. Affected individuals have high risk for cancers of the colon and certain extracolonic sites. It appears that HNPCC patients form adenomas at about the same rate as the general population and there is circumstantial evidence that adenoma is the precursor to colorectal carcinoma in the syndrome. It is hypothesized that HNPCC features accelerated progression from colonic adenoma to carcinoma, a process theoretically driven by the inability to repair DNA mismatches. Evidence in support of the ''Aggressive Adenoma'' in HNPCC is provided. We discuss our recommendations for colonoscopic surveillance on an annual basis for HNPCC gene-positive individuals, and for genetic counseling. (C) 1995 Wiley-Liss, Inc.

引用

页码：406 / 410

页数：5

共 24 条

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