DOPAMINE RECEPTOR AGONISTS .1. SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 4-ARYL-SUBSTITUTED ANALOGS OF 6,7-DIHYDROXY-2-AMINOTETRALIN (6,7-ADTN) AND RELATED INDANE COMPOUNDS

被引：7

作者：

BERTOLINI, G

VECCHIETTI, V

MABILIA, M

NORCINI, G

RESTELLI, A

SANTANGELO, F

VILLA, AM

CASAGRANDE, C

机构：

[1] ZAMBON RES, DEPT MED CHEM, VIA DUCA 10, I-20091 BRESSO, ITALY

[2] ZAMBON GRP SPA, IST RIC CHIM G ZAMBON, I-20032 CORMANO, ITALY

[3] UNIV MILANO, IST CHIM FARMACEUT, I-20100 MILAN, ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1992年 / 27卷 / 07期

关键词：

DOPAMINE; ARYL RIGID DOPAMINE ANALOGS; MOLECULAR MODELING;

D O I：

10.1016/0223-5234(92)90086-G

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives of cis- and trans-4-phenyl-6,7-dihydroxy-2-aminotetraline and trans-1-phenyl-5,6-dihydroxy-2-aminoindane were synthetized as fenoldopam analogues. They showed no affinity for D, and D2 binding sites in rat striatal membranes. Molecular modeling and NMR methods used in structural comparison with fenoldopam are discussed.

引用

页码：663 / 672

页数：10

共 12 条

[1] SYNTHESIS AND RECEPTOR AFFINITIES OF SOME CONFORMATIONALLY RESTRICTED ANALOGS OF THE DOPAMINE D1 SELECTIVE LIGAND (5R)-8-CHLORO-2,3,4,5-TETRAHYDRO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL [J].