PARATHYROID HORMONE-RELATED PROTEIN IS A POSSIBLE AUTOCRINE GROWTH INHIBITOR FOR LYMPHOCYTES

被引：76

作者：

ADACHI, N ^{[1
]}

YAMAGUCHI, K ^{[1
]}

MIYAKE, Y ^{[1
]}

HONDA, S ^{[1
]}

NAGASAKI, K ^{[1
]}

AKIYAMA, Y ^{[1
]}

ADACHI, I ^{[1
]}

ABE, K ^{[1
]}

机构：

[1] NATL CANC CTR,DEPT MED,TOKYO 104,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0006-291X(90)90978-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adult T-cell leukemia (ATL)-related cells have the ability to produce a newly-isolated calcium-regulating protein, parathyroid hormonerelated protein (PTHrP). The present study revealed that lectin-stimulated normal lymphocytes produce immunoreactive (IR)-PTHrP. When the T-cell-enriched fraction was purified from normal lymphocytes and then treated with lectin, a similar amount of IR-PTHrP was detected, suggesting that IR-PTHrP is an actual product of T-lymphocytes. A biologically active fragment of PTHrP, PTHrP(1-34), suppressed DNA synthesis in lectin-stimulated lymphocytes at concentrations greater than 50 pg/mL; the same concentration range of IR-PTHrP detected in the cultured media of lectin-stimulated lymphocytes. Therefore, it is reasonable to postulate that PTHrP is a cytokine inhibiting the cellular growth of normal lymphocytes. © 1990.

引用

页码：1088 / 1094

页数：7

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