HETEROGENEITY OF TAU PROTEINS DURING MOUSE-BRAIN DEVELOPMENT AND DIFFERENTIATION OF CULTURED NEURONS

被引:38
作者
LARCHER, JC [1 ]
BOUCHER, D [1 ]
GINZBURG, I [1 ]
GROS, F [1 ]
DENOULET, P [1 ]
机构
[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL
关键词
D O I
10.1016/0012-1606(92)90059-P
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tau microtubule-associated proteins constitute a group of developmentally regulated neuronal proteins. Using the high-resolution two-dimensional polyacrylamide gel electrophoresis system, we have resolved more than 60 distinct Tau isoforms in the adult mouse brain. Tau protein heterogeneity increases drastically during the second week of brain development. In neuronal primary cell cultures, some of these developmental changes can be observed. The increase of Tau heterogeneity in culture is more limited and reaches a plateau after a period corresponding to the second week of development. Most, if not all, of the vast Tau heterogeneity can be attributed to intensive post-translational phosphorylation, which may affect the structure of the proteins. © 1992.
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页码:195 / 204
页数:10
相关论文
共 44 条
[31]   MICROTUBULES AND BRAIN-DEVELOPMENT - THE EFFECTS OF THYROID-HORMONES [J].
NUNEZ, J .
NEUROCHEMISTRY INTERNATIONAL, 1985, 7 (06) :959-968
[32]  
NUNEZ J, 1987, HORMONES CELL REGULA, V153, P181
[33]   HIGH-RESOLUTION 2-DIMENSIONAL ELECTROPHORESIS OF BASIC AS WELL AS ACIDIC PROTEINS [J].
OFARRELL, PZ ;
GOODMAN, HM ;
OFARRELL, PH .
CELL, 1977, 12 (04) :1133-1141
[34]   INTERACTION OF BRAIN CYTOPLASMIC DYNEIN AND MAP2 WITH A COMMON SEQUENCE AT THE C-TERMINUS OF TUBULIN [J].
PASCHAL, BM ;
OBAR, RA ;
VALLEE, RB .
NATURE, 1989, 342 (6249) :569-572
[35]   CHARACTERIZATION OF A MAJOR BRAIN TUBULIN VARIANT WHICH CANNOT BE TYROSINATED [J].
PATURLELAFANECHERE, L ;
EDDE, B ;
DENOULET, P ;
VANDORSSELAER, A ;
MAZARGUIL, H ;
LECAER, JP ;
WEHLAND, J ;
JOB, D .
BIOCHEMISTRY, 1991, 30 (43) :10523-10528
[36]   ENZYME TYROSYLATING ALPHA-TUBULIN AND ITS ROLE IN MICROTUBULE ASSEMBLY [J].
RAYBIN, D ;
FLAVIN, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 65 (03) :1088-1095
[37]   LOCALIZATION OF THE TUBULIN BINDING-SITE FOR TAU-PROTEIN [J].
SERRANO, L ;
DEGARCINI, EM ;
HERNANDEZ, MA ;
AVILA, J .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 153 (03) :595-600
[38]   MICROTUBULE ASSEMBLY IN ABSENCE OF ADDED NUCLEOTIDES [J].
SHELANSK.ML ;
GASKIN, F ;
CANTOR, CR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :765-768
[39]   PHOSPHORYLATION OF MICROTUBULE-ASSOCIATED PROTEIN-TAU - IDENTIFICATION OF THE SITE FOR CA-2+-CALMODULIN DEPENDENT KINASE AND RELATIONSHIP WITH TAU-PHOSPHORYLATION IN ALZHEIMER TANGLES [J].
STEINER, B ;
MANDELKOW, EM ;
BIERNAT, J ;
GUSTKE, N ;
MEYER, HE ;
SCHMIDT, B ;
MIESKES, G ;
SOLING, HD ;
DRECHSEL, D ;
KIRSCHNER, MW ;
GOEDERT, M ;
MANDELKOW, E .
EMBO JOURNAL, 1990, 9 (11) :3539-3544
[40]  
SULLIVAN KF, 1988, ANNU REV CELL BIOL, V4, P687, DOI 10.1146/annurev.cellbio.4.1.687