RENAL VASODILATATION IN RESPONSE TO ACUTE VOLUME LOAD IS ATTENUATED FOLLOWING LESIONS OF PARVOCELLULAR NEURONS IN THE PARAVENTRICULAR NUCLEUS IN RATS

被引:76
作者
LOVICK, TA
MALPAS, S
MAHONY, MT
机构
[1] Department of Physiology, The Medical School, Birmingham
来源
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM | 1993年 / 43卷 / 03期
基金
英国惠康基金;
关键词
PARAVENTRICULO-SPINAL NEURON; RENAL BLOOD FLOW; VOLUME REGULATION; CARDIOVASCULAR CONTROL;
D O I
10.1016/0165-1838(93)90331-N
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect on the cardiovascular response to volume load, of lesioning the paraventriculo-spinal projection to the lower thoracic cord, has been investigated in urethane-anaesthetised rats. In control animals volume loading with 4% Ficoll 70 in 165 mM NaCl at 0.6 ml/min iv. up to 1% body weight produced a pressor response and tachycardia accompanied by a vasodilatation in the renal vascular bed. Injections of 2-4 mug ibotenic acid in 100-200 mul solution were made into the paraventricular nucleus to lesion parvocellular neurones. When tested 3 days after the lesioning procedure, the renal vasodilator component of the response to volume load was abolished, although blood pressure and heart rate still rose. When the response to volume load was tested 28 days after the lesion, some degree of functional recovery appeared to have taken place. In these rats there was a weak renal vasodilation although the maximal increase in renal vascular conductance (20 +/- 13%) was still smaller than in the control animals. The efficacy of the lesioning procedure was verified by counting the number of fluorescent labelled neurones in PVN after injection of 1-2 mul of a 1.25% solution of the retrograde marker 4,6 diamidino-2-phenyl indole (DAPI) bilaterally into the cord at T8-10. 1005 +/- 63 neurones were present in each side of PVN in non-PVN-lesioned rats whilst in lesioned animals only 444 +/- 153 cells were present. These results suggest that the paraventriculo-spinal projection to the lower thoracic cord may play an important role in sympathetically mediated changes in renal blood flow during the early phase of the response to an acute volume load.
引用
收藏
页码:247 / 255
页数:9
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