POSITIVITY OF PATCH TESTS IN CUTANEOUS REACTION TO DICLOFENAC - 2 CASE-REPORTS

被引：31

作者：

ROMANO, A

PIETRANTONIO, F

DIFONSO, M

GARCOVICH, A

CHIARELLI, C

VENUTI, A

BARONE, C

机构：

[1] UNIV CATTOLICA SACRO CUORE,IST CLIN MED,I-00168 ROME,ITALY

[2] UNIV CATTOLICA S CUORE,IST DERMATOL,ROME,ITALY

[3] UNIV CATTOLICA S CUORE,IST ANAT PATOL,ROME,ITALY

来源：

ALLERGY | 1994年 / 49卷 / 01期

关键词：

DICLOFENAC; HYPERSENSITIVITY REACTION; SKIN TESTS;

D O I：

10.1111/j.1398-9995.1994.tb00774.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Immune-mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48-72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.

引用

页码：57 / 59

页数：3

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