STRUCTURE-BASED DESIGN OF HIV PROTEASE INHIBITORS - 4-HYDROXYCOUMARINS AND 4-HYDROXY-2-PYRONES AS NONPEPTIDIC INHIBITORS

被引：146

作者：

THAISRIVONGS, S

TOMICH, PK

WATENPAUGH, KD

CHONG, KT

HOWE, WJ

YANG, CP

STROHBACH, JW

TURNER, SR

MCGRATH, JP

BOHANON, MJ

LYNN, JC

MULICHAK, AM

SPINELLI, PA

HINSHAW, RR

PAGANO, PJ

MOON, JB

RUWART, MJ

WILKINSON, KF

RUSH, BD

ZIPP, GL

DALGA, RJ

SCHWENDE, FJ

HOWARD, GM

PADBURY, GE

TOTH, LN

ZHAO, ZY

KOEPLINGER, KA

KAKUK, TJ

COLE, SL

ZAYA, RM

PIPER, RC

JEFFREY, P

机构：

[1] UPJOHN CO,UPJOHN LABS,CHEM & BIOL SCREEN,KALAMAZOO,MI 49001

[2] UPJOHN CO,UPJOHN LABS,PHYS & ANALYT CHEM,KALAMAZOO,MI 49001

[3] UPJOHN CO,UPJOHN LABS,CANC & INFECT DIS RES,KALAMAZOO,MI 49001

[4] UPJOHN CO,UPJOHN LABS,COMP AIDED DRUG DESIGN,KALAMAZOO,MI 49001

[5] UPJOHN CO,UPJOHN LABS,DRUG DELIVERY SYST RES,KALAMAZOO,MI 49001

[6] UPJOHN CO,UPJOHN LABS,PHARMACEUT,KALAMAZOO,MI 49001

[7] UPJOHN CO,UPJOHN LABS,DRUG METAB RES,KALAMAZOO,MI 49001

[8] UPJOHN CO,UPJOHN LABS,DRUG DEV TOXICOL,KALAMAZOO,MI 49001

[9] UPJOHN CO,UPJOHN LABS,PHARMACOKINET & BIOPHARMACEUT,CRAWLEY,W SUSSEX,ENGLAND

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 20期

关键词：

D O I：

10.1021/jm00046a002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3200 / 3204

页数：5

共 27 条

[11] SYMMETRY-BASED INHIBITORS OF HIV PROTEASE - STRUCTURE ACTIVITY STUDIES OF ACYLATED 2,4-DIAMINO-1,5-DIPHENYL-3-HYDROXYPENTANE AND 2,5-DIAMINO-1,6-DIPHENYLHEXANE-3,4-DIOL
KEMPF, DJ
CODACOVI, L
WANG, XC
KOHLBRENNER, WE
WIDEBURG, NE
SALDIVAR, A
VASAVANONDA, S
MARSH, KC
BRYANT, P
SHAM, HL
GREEN, BE
BETEBENNER, DA
ERICKSON, J
NORBECK, DW
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (03) : 320 - 330
[12] RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS
LAM, PYS
JADHAV, PK
EYERMANN, CJ
HODGE, CN
RU, Y
BACHELER, LT
MEEK, JL
OTTO, MJ
RAYNER, MM
WONG, YN
CHANG, CH
WEBER, PC
JACKSON, DA
SHARPE, TR
ERICKSONVIITANEN, S
[J]. SCIENCE, 1994, 263 (5145) : 380 - 384
[13] RECENT ADVANCES IN THE DESIGN OF HIV PROTEINASE-INHIBITORS
MARTIN, JA
[J]. ANTIVIRAL RESEARCH, 1992, 17 (04) : 265 - 278
[14] EFFECTS OF U-75875, A PEPTIDOMIMETIC INHIBITOR OF RETROVIRAL PROTEASES, ON SIMIAN IMMUNODEFICIENCY VIRUS-INFECTION IN RHESUS-MONKEYS
MARTIN, LN
SOIKE, KF
MURPHEYCORB, M
BOHM, RP
ROBERTS, ED
KAKUK, TJ
THAISRIVONGS, S
VIDMAR, TJ
RUWART, MJ
DAVIO, SR
TARPLEY, WG
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (06) : 1277 - 1283
[15] INHIBITORS OF HIV-1 PROTEASE
MEEK, TD
[J]. JOURNAL OF ENZYME INHIBITION, 1992, 6 (01): : 65 - 98
[16] MIMOTO T, 1992, CHEM PHARM BULL, V40, P2251
[17] NORBECK D, 1992, 8 INT C AIDS AMST
[18] PAPAIN I, 1967, BIOCHEM BIOPH RES CO, V27, P157
[19] PLATTNER JJ, 1990, DRUG DISCOVERY TECHN, P92
[20] ROBINS T, 1993, J ACQ IMMUN DEF SYND, V6, P162

← 1 2 3 →