LOSS OF CHROMOSOME-22 IN PATIENTS WITH REFRACTORY-ANEMIA WITH EXCESS OF BLASTS (RAEB) IN TRANSFORMATION AND ACUTE-LEUKEMIA AFTER RAEB

被引：5

作者：

BERGER, R ^{[1
]}

LECONIAT, M ^{[1
]}

DERRE, J ^{[1
]}

FLEXOR, MA ^{[1
]}

机构：

[1] CNRS,SDI 15954,INST GENET MOLEC,PARIS,FRANCE

来源：

CANCER GENETICS AND CYTOGENETICS | 1992年 / 61卷 / 02期

关键词：

D O I：

10.1016/0165-4608(92)90090-U

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report studies of 12 patients with refractory anemia and excess of blasts in transformation (RAEB-t) and 17 with acute myeloblastic leukemia (AML) after RAEB. Besides chromosome 5 and 7 abnormalities, five patients with complex karyotypic changes had monosomy 22. This association is discussed in relation to the hypothesis of a suppressor gene located on chromosome 22.

引用

页码：210 / 212

页数：3

共 17 条

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