BRAIN LITHIUM CONCENTRATIONS MEASURED WITH LI-7 MAGNETIC-RESONANCE SPECTROSCOPY IN PATIENTS WITH AFFECTIVE-DISORDERS - RELATIONSHIP TO ERYTHROCYTE AND SERUM CONCENTRATIONS

被引：36

作者：

KATO, T ^{[1
]}

SHIOIRI, T ^{[1
]}

INUBUSHI, T ^{[1
]}

TAKAHASHI, S ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,MOLEC NEUROBIOL RES CTR,OTSU,SHIGA 52021,JAPAN

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 03期

关键词：

LITHIUM; MAGNETIC RESONANCE SPECTROSCOPY; RED BLOOD CELL; BIPOLAR AFFECTIVE DISORDER;

D O I：

10.1016/0006-3223(93)90133-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain lithium concentrations were measured in eight patients with affective disorders using lithium-7 magnetic resonance spectroscopy (MRS). Brain lithium concentrations correlated better with serum concentrations (n = 23, r = 0.66, p < 0.001) than with erythrocyte concentrations (r = 0.44, p < 0.05). Because of previous data in animal experiments these results were unexpected, but the differences in cation transport mechanisms between neurons and erythrocytes may account for the results.

引用

页码：147 / 152

页数：6