THE BARR BODY IS A LOOPED X-CHROMOSOME FORMED BY TELOMERE ASSOCIATION

被引：68

作者：

WALKER, CL

CARGILE, CB

FLOY, KM

DELANNOY, M

MIGEON, BR

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT CELL BIOL,BALTIMORE,MD 21205

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 14期

关键词：

CHROMOSOME STRUCTURE; X-INACTIVATION; CENTROMERE; INTERPHASE CYTOGENETICS; INSITU HYBRIDIZATION;

D O I：

10.1073/pnas.88.14.6191

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We examined Barr bodies formed by isodicentric human X chromosomes in cultured human cells and in mouse-human hybrids using confocal microscopy and DNA probes for centromere and subtelomere regions. At interphase, the two ends of these chromosomes are only a micron apart, indicating that these inactive X chromosomes are in a nonlinear configuration. Additional studies of normal X chromosomes reveal the same telomere association for the inactive X but not for the active X chromosome. This nonlinear configuration is maintained during mitosis and in a murine environment.

引用

页码：6191 / 6195

页数：5

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