DRUG DELIVERY SYSTEMS USING HYALURONAN AND ITS DERIVATIVES

被引:86
作者
LARSEN, NE
BALAZS, EA
机构
[1] Matrix Biology Institute, Ridgefield
关键词
CONTROLLED RELEASE; HYALURONAN; HYALIN; VISCOELASTIC; BIOCOMPATIBLE; INJECTABLE; IMPLANTABLE; PHARMACEUTICAL;
D O I
10.1016/0169-409X(91)90007-Y
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hyaluronan (sodium hyaluronate) and hyaluronan derivatives (hylans) have been developed as topical, injectable and implantable vehicles for the controlled and localized delivery of biologically active molecules. Hyaluronan is a natural polysaccharide which exhibits extraordinary biocompatibility and unique rheological properties. Hylans are a family of chemically modified hyaluronans and include hylan fluids, gels, microparticles and membranes (sheets, coatings). Hylan fluid is a water-soluble, hydrophilic, polyanionic hyaluronan derivative which retains the excellent biocompatibility of the native glycosaminoglycan while providing the basis for various release systems. Hyaluronan and hylan derivatives have been evaluated in in vitro and in vivo models for their ability to optimize delivery of a variety of pharmacologically active molecules including the antibiotic gentamicin, the antiglaucoma drugs pilocarpine and betaxolol, the vasodilator serotonin (5-hydroxytryptamine), the cytokine interferon and the enzyme thrombin.
引用
收藏
页码:279 / 293
页数:15
相关论文
共 43 条
  • [11] BLOOMFIELD SE, 1978, ARCH OPHTHALMOL-CHIC, V96, P885
  • [12] BLOOMFIELD SE, 1978, SOLUBLE GENTAMICIN O
  • [13] SODIUM HYALURONATE AS AN OPHTHALMIC VEHICLE - SOME FACTORS GOVERNING ITS EFFECT ON THE OCULAR ABSORPTION OF PILOCARPINE
    CAMBER, O
    EDMAN, P
    [J]. CURRENT EYE RESEARCH, 1989, 8 (06) : 563 - 567
  • [14] CHRAI SS, 1974, J PHARM SCI, V63, P1218, DOI 10.1002/jps.2600630810
  • [15] LACRIMAL AND INSTILLED FLUID DYNAMICS IN RABBIT EYES
    CHRAI, SS
    PATTON, TF
    MEHTA, A
    ROBINSON, JR
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (07) : 1112 - 1121
  • [16] Conrad J M, 1978, J Parenter Drug Assoc, V32, P149
  • [17] DELUISE VP, 1984, ANN OPHTHALMOL, V16, P823
  • [18] EMBOLIZATION BY SUPERSELECTIVE ARTERIOGRAPHY FROM FEMORAL ROUTE IN NEURORADIOLOGY - REVIEW OF 60 CASES .1. TECHNIQUE, INDICATIONS, COMPLICATIONS
    DJINDJIAN, R
    COPHIGNON, J
    THERON, J
    MERLAND, JJ
    HOUDART, R
    [J]. NEURORADIOLOGY, 1973, 6 (01) : 20 - 26
  • [19] EIFE R, 1981, J IMMUNOL METHODS, V47, P339, DOI 10.1016/0022-1759(81)90290-8
  • [20] RHEOLOGY OF HYALURONIC ACID
    GIBBS, DA
    MERRILL, EW
    SMITH, KA
    BALAZS, EA
    [J]. BIOPOLYMERS, 1968, 6 (06) : 777 - &