EFFECTS OF RP-67580 ON SUBSTANCE-P ELICITED RESPONSES AND POSTSYNAPTIC POTENTIALS OF MOTONEURONS OF THE RAT ISOLATED SPINAL-CORD

被引：5

作者：

BARANAUSKAS, G ^{[1
]}

NISTRI, A ^{[1
]}

机构：

[1] SCUOLA INT SUPER STUDI AVANZATI,BIOPHYS SECTOR,I-34013 TRIESTE,ITALY

来源：

PEPTIDES | 1995年 / 16卷 / 02期

关键词：

SUBSTANCE P; TACHYKININ; NEUROPEPTIDE; MOTOR SYSTEM; MOTONEURON;

D O I：

10.1016/0196-9781(94)00194-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of RP 67580, a recently developed antagonist selective for the NK, tachykinin receptors of peripheral tissues, was studied with intracellular recording from motoneurones of the rat isolated spinal cord. In the presence of RP 67580 (1-2 mu M), membrane depolarization induced by the putative transmitter substance P (SP) was either unchanged or enhanced (an effect prevented by tetrodotoxin; TTX). Neither short nor long excitatory synaptic potentials (EPSPs) were antagonized by RP 67580. Sustained synaptically evoked depolarizations (mimicking noxious stimuli and thus presumed to be at least partly mediated by SP) were also insensitive to RP 67580. These data suggest the existence of a pharmacologically distinct NK1 receptor population (insensitive to RP 67580) in the neonatal rat spinal cord.

引用

页码：357 / 359

页数：3

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