A TOTAL SYNTHESIS OF 2'-DEOXY-9-DEAZAGUANOSINE (9-DEAZA-DG) AND ITS INCORPORATION INTO TRIPLE-HELIX FORMING OLIGODEOXYRIBONUCLEOTIDES WITH ANTIPARALLEL MOTIF

被引：20

作者：

RAO, TS ^{[1
]}

LEWIS, AF ^{[1
]}

DURLAND, RH ^{[1
]}

REVANKAR, GR ^{[1
]}

机构：

[1] TRIPLEX PHARMACEUT CORP,9391 GROGANS MILL RD,THE WOODLANDS,TX 77380

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 42期

关键词：

D O I：

10.1016/S0040-4039(00)61681-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple synthesis of 2-amino-7-(2-deoxy-beta-D-erythro-pentofuranosyl)pyrrolo[3,2-d]pyrimidin-4(3H)-one (9-deaza-dG) has been achieved and it has been incorporated into triplex forming oligonucleotides using the solid-support, phosphoramidite chemistry. 9-Deaza-dG is effective in preventing the formation of G-tetrads in G-rich oligonucleotides.

引用

页码：6709 / 6712

页数：4

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