AMLODIPINE - A NEW CALCIUM-ANTAGONIST

被引:36
作者
CLAVIJO, GA
DECLAVIJO, IV
WEART, CW
机构
[1] BROWARD FAMILY HLTH CTR,FT LAUDERDALE,FL
[2] MT SINAI MED CTR,MIAMI BEACH,FL 33140
[3] MED UNIV S CAROLINA,DEPT FAMILY MED,CHARLESTON,SC 29425
[4] MED UNIV S CAROLINA,DEPT COMMUNITY PHARM PRACTICE & ADM,CHARLESTON,SC 29425
来源
AMERICAN JOURNAL OF HOSPITAL PHARMACY | 1994年 / 51卷 / 01期
关键词
AMLODIPINE; ANGINA PECTORIS; CARDIAC DRUGS; HYPERTENSION; PHARMACOKINETICS; TOXICITY;
D O I
10.1093/ajhp/51.1.59
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The chemistry, pharmacology, pharmacokinetics, efficacy, and adverse effects of amlodipine are reviewed. Amlodipine belongs to the dihydropyridine subclass of calcium antagonists. Amlodipine is a potent peripheral and coronary vasodilator with high selectivity for vascular smooth muscle and minimal effect on myocardial contractility or cardiac conduction. Absorption after oral administration is slow, and the duration of action is long, with a half-life of 36-45 hours. Amlodipine has FDA-approved labeling for use in the treatment of hypertension, chronic stable angina, and vasospastic angina. The agent is also indicated for use in hypertensive or anginal patients who also have congestive heart failure due to systolic dysfunction (New York Heart Association classes Il and III). Clinical trials suggest that effective 24-hour control of hypertension and angina is provided by once-daily administration of amlodipine 5-10 mg alone or in combination with other drugs. No clinically important drug interactions have been observed to date. Amlodipine has not shown any unfavorable effects on serum glucose or lipid levels. The most common adverse effect is peripheral edema. Amlodipine is effective and well tolerated when given alone or in combination with other drugs for the treatment of hypertension and angina. Amlodipine may offer advantages over verapamil, diltiazem, and nifedipine in patients with hypertension or angina with associated congestive heart failure due to systolic dysfunction.
引用
收藏
页码:59 / 68
页数:10
相关论文
共 90 条
  • [11] EFFICACY AND SAFETY OF AMLODIPINE IN VASOSPASTIC ANGINA - AN INTERIM-REPORT OF A MULTICENTER, PLACEBO-CONTROLLED TRIAL
    CHAHINE, RA
    FELDMAN, RL
    GILES, TD
    RAIZNER, AE
    WEISS, RJ
    NICOD, P
    [J]. AMERICAN HEART JOURNAL, 1989, 118 (05) : 1128 - 1130
  • [12] RANDOMIZED PLACEBO-CONTROLLED TRIAL OF AMLODIPINE IN VASOSPASTIC ANGINA
    CHAHINE, RA
    FELDMAN, RL
    GILES, TD
    NICOD, P
    RAIZNER, AE
    WEISS, RJ
    VANOV, SK
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1993, 21 (06) : 1365 - 1370
  • [13] INFLUENCE OF SEVERITY OF VENTRICULAR DYSFUNCTION ON HEMODYNAMIC-RESPONSES TO INTRAVENOUSLY ADMINISTERED VERAPAMIL IN ISCHEMIC-HEART-DISEASE
    CHEW, CYC
    HECHT, HS
    COLLETT, JT
    MCALLISTER, RG
    SINGH, BN
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1981, 47 (04) : 917 - 922
  • [14] ANTIHYPERTENSIVE EFFECTIVENESS OF AMLODIPINE IN COMBINATION WITH HYDROCHLOROTHIAZIDE
    CHRYSANT, SG
    CHRYSANT, C
    TRUS, J
    HITCHCOCK, A
    [J]. AMERICAN JOURNAL OF HYPERTENSION, 1989, 2 (07) : 537 - 541
  • [15] A DOUBLE-BLIND DOSE-RESPONSE STUDY OF AMLODIPINE IN PATIENTS WITH STABLE ANGINA-PECTORIS
    COCCO, G
    ALFIERO, R
    [J]. EUROPEAN HEART JOURNAL, 1991, 12 (02) : 169 - 174
  • [16] THE EFFECTS OF ANTIHYPERTENSIVE THERAPY ON THE QUALITY-OF-LIFE
    CROOG, SH
    LEVINE, S
    TESTA, MA
    BROWN, B
    BULPITT, CJ
    JENKINS, CD
    KLERMAN, GL
    WILLIAMS, GH
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (26) : 1657 - 1664
  • [17] DEBRUIJN B, 1988, J CARDIOVASC PHAR S7, V12, P107
  • [18] EFFECTS OF DIFFERENT CALCIUM-ANTAGONISTS ON PROTEINURIA ASSOCIATED WITH DIABETES-MELLITUS
    DEMARIE, BK
    BAKRIS, GL
    [J]. ANNALS OF INTERNAL MEDICINE, 1990, 113 (12) : 987 - 988
  • [19] AMLODIPINE COMBINED WITH BETA-BLOCKADE FOR CHRONIC ANGINA - RESULTS OF A MULTICENTER, PLACEBO-CONTROLLED, RANDOMIZED DOUBLE-BLIND-STUDY
    DIBIANCO, R
    SCHOOMAKER, FW
    SINGH, JB
    AWAN, NA
    BENNETT, T
    CANOSA, FL
    KAWANISHI, DT
    BAMRAH, VS
    GLASSER, SP
    BARRY, W
    [J]. CLINICAL CARDIOLOGY, 1992, 15 (07) : 519 - 524
  • [20] PHARMACOKINETICS OF AMLODIPINE IN RENAL IMPAIRMENT
    DOYLE, GD
    DONOHUE, J
    CARMODY, M
    LAHER, M
    GREB, H
    VOLZ, M
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (02) : 205 - 208