We report that NO synthase activity, as expressed by citrulline and nitrite formation in brain homogenates, is decreased in 24-month old in comparison to 3-month old rats. In particular, a Ca++-dependent NO synthase activity was detected in homogenates obtained from cortical, hippocampal, cerebellar and lower brain stem slices from both 3- and 24 month - old rats. The amount of citrulline generated from L-arginine was significantly decreased in the hippocampus and lower brain stem by 40 and 48%, respectively. No changes were observed in NO synthase activity in cortical and cerebellar homogenates. Thus, the L-arginine-NO pathway seems to be impaired in selected areas of rat brain and this may contribute to the understanding of pathophysiological mechanisms underlying age-related cerebral disorders. (C) 1995 Academic Press. Inc.
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
BAGETTA, G
IANNONE, M
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
IANNONE, M
SCORSA, AM
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
SCORSA, AM
NISTICO, G
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
BAGETTA, G
IANNONE, M
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
IANNONE, M
SCORSA, AM
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY
SCORSA, AM
NISTICO, G
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UNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALYUNIV ROME TOR VERGATA,DEPT BIOL,CHAIR PHARMACOL,VIA E CARNEVALE,I-00173 ROME,ITALY