AGE-DEPENDENT CHANGES OF NO SYNTHASE ACTIVITY IN THE RAT-BRAIN

被引：49

作者：

MOLLACE, V ^{[1
]}

RODINO, P ^{[1
]}

MASSOUD, R ^{[1
]}

ROTIROTI, D ^{[1
]}

NISTICO, G ^{[1
]}

机构：

[1] UNIV REGGIO CALABRIA,FAC PHARM,CNR,IBAF CTR,CATANZARO,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report that NO synthase activity, as expressed by citrulline and nitrite formation in brain homogenates, is decreased in 24-month old in comparison to 3-month old rats. In particular, a Ca++-dependent NO synthase activity was detected in homogenates obtained from cortical, hippocampal, cerebellar and lower brain stem slices from both 3- and 24 month - old rats. The amount of citrulline generated from L-arginine was significantly decreased in the hippocampus and lower brain stem by 40 and 48%, respectively. No changes were observed in NO synthase activity in cortical and cerebellar homogenates. Thus, the L-arginine-NO pathway seems to be impaired in selected areas of rat brain and this may contribute to the understanding of pathophysiological mechanisms underlying age-related cerebral disorders. (C) 1995 Academic Press. Inc.

引用

页码：822 / 827

页数：6

共 15 条

[1] BRAIN AGING AND NEURONAL PLASTICITY
AGNATI, LF
BENFENATI, F
SOLFRINI, V
BIAGINI, G
FUXE, K
GUIDOLIN, D
CARANI, C
ZINI, I
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 180 - 186
[2] TACRINE-INDUCED SEIZURES AND BRAIN-DAMAGE IN LICL-TREATED RATS CAN BE PREVENTED BY N-OMEGA-NITRO-L-ARGININE METHYL-ESTER
BAGETTA, G
IANNONE, M
SCORSA, AM
NISTICO, G
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 213 (02) : 301 - 304
[3] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME
BREDT, DS
SNYDER, SH
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 682 - 685
[4] Calza L., 1993, Society for Neuroscience Abstracts, V19, P898
[5] TRANSMEMBRANE SIGNALING CHANGES WITH AGING
FULOP, T
BARABAS, G
VARGA, Z
CSONGOR, J
HAUCK, M
SZUCS, S
SERES, I
MOHACSI, A
KEKESSY, D
DESPONT, JP
ROBERT, L
PENYIGE, A
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 165 - 171
[6] LOCALIZATION OF NADPH DIAPHORASE IN NEURONS OF THE ROSTRAL VENTRAL MEDULLA - POSSIBLE ROLE OF NITRIC-OXIDE IN CENTRAL AUTONOMIC REGULATION AND OXYGEN CHEMORECEPTION
IADECOLA, C
FARIS, PL
HARTMAN, BK
XU, XH
[J]. BRAIN RESEARCH, 1993, 603 (01) : 173 - 179
[7] THE AGE DECLINE IN MEMORY - CAN IT BE ELIMINATED
KNOPF, M
[J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 172 - 179
[8] LIBRI V, 1993, PHARM COMMUN, V3, P81
[9] THE EFFECTS OF PHOSPHATIDYLSERINE ON THE DECREASED CARDIOVASCULAR-RESPONSE TO CLONIDINE MICROINFUSED INTO THE NUCLEUS TRACTUS SOLITARII OF OLD RATS
MOLLACE, V
MASUDA, Y
PELAGGI, T
NISTICO, G
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (03) : 547 - 551
[10] AGE-DEPENDENT CHANGES IN CARDIOVASCULAR-RESPONSES INDUCED BY MUSCIMOL INFUSED INTO THE NUCLEUS-TRACTUS-SOLITARII AND NUCLEUS PARABRACHIALIS MEDIALIS IN RATS
MOLLACE, V
DEFRANCESCO, EA
FERSINI, G
NISTICO, G
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (03) : 1802 - 1806

← 1 2 →