AGE-DEPENDENT CHANGES OF NO SYNTHASE ACTIVITY IN THE RAT-BRAIN

被引:49
作者
MOLLACE, V [1 ]
RODINO, P [1 ]
MASSOUD, R [1 ]
ROTIROTI, D [1 ]
NISTICO, G [1 ]
机构
[1] UNIV REGGIO CALABRIA,FAC PHARM,CNR,IBAF CTR,CATANZARO,ITALY
关键词
D O I
10.1006/bbrc.1995.2537
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We report that NO synthase activity, as expressed by citrulline and nitrite formation in brain homogenates, is decreased in 24-month old in comparison to 3-month old rats. In particular, a Ca++-dependent NO synthase activity was detected in homogenates obtained from cortical, hippocampal, cerebellar and lower brain stem slices from both 3- and 24 month - old rats. The amount of citrulline generated from L-arginine was significantly decreased in the hippocampus and lower brain stem by 40 and 48%, respectively. No changes were observed in NO synthase activity in cortical and cerebellar homogenates. Thus, the L-arginine-NO pathway seems to be impaired in selected areas of rat brain and this may contribute to the understanding of pathophysiological mechanisms underlying age-related cerebral disorders. (C) 1995 Academic Press. Inc.
引用
收藏
页码:822 / 827
页数:6
相关论文
共 15 条
  • [1] BRAIN AGING AND NEURONAL PLASTICITY
    AGNATI, LF
    BENFENATI, F
    SOLFRINI, V
    BIAGINI, G
    FUXE, K
    GUIDOLIN, D
    CARANI, C
    ZINI, I
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 180 - 186
  • [2] TACRINE-INDUCED SEIZURES AND BRAIN-DAMAGE IN LICL-TREATED RATS CAN BE PREVENTED BY N-OMEGA-NITRO-L-ARGININE METHYL-ESTER
    BAGETTA, G
    IANNONE, M
    SCORSA, AM
    NISTICO, G
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 213 (02) : 301 - 304
  • [3] ISOLATION OF NITRIC-OXIDE SYNTHETASE, A CALMODULIN-REQUIRING ENZYME
    BREDT, DS
    SNYDER, SH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (02) : 682 - 685
  • [4] Calza L., 1993, Society for Neuroscience Abstracts, V19, P898
  • [5] TRANSMEMBRANE SIGNALING CHANGES WITH AGING
    FULOP, T
    BARABAS, G
    VARGA, Z
    CSONGOR, J
    HAUCK, M
    SZUCS, S
    SERES, I
    MOHACSI, A
    KEKESSY, D
    DESPONT, JP
    ROBERT, L
    PENYIGE, A
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 165 - 171
  • [6] LOCALIZATION OF NADPH DIAPHORASE IN NEURONS OF THE ROSTRAL VENTRAL MEDULLA - POSSIBLE ROLE OF NITRIC-OXIDE IN CENTRAL AUTONOMIC REGULATION AND OXYGEN CHEMORECEPTION
    IADECOLA, C
    FARIS, PL
    HARTMAN, BK
    XU, XH
    [J]. BRAIN RESEARCH, 1993, 603 (01) : 173 - 179
  • [7] THE AGE DECLINE IN MEMORY - CAN IT BE ELIMINATED
    KNOPF, M
    [J]. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 673 : 172 - 179
  • [8] LIBRI V, 1993, PHARM COMMUN, V3, P81
  • [9] THE EFFECTS OF PHOSPHATIDYLSERINE ON THE DECREASED CARDIOVASCULAR-RESPONSE TO CLONIDINE MICROINFUSED INTO THE NUCLEUS TRACTUS SOLITARII OF OLD RATS
    MOLLACE, V
    MASUDA, Y
    PELAGGI, T
    NISTICO, G
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1990, 100 (03) : 547 - 551
  • [10] AGE-DEPENDENT CHANGES IN CARDIOVASCULAR-RESPONSES INDUCED BY MUSCIMOL INFUSED INTO THE NUCLEUS-TRACTUS-SOLITARII AND NUCLEUS PARABRACHIALIS MEDIALIS IN RATS
    MOLLACE, V
    DEFRANCESCO, EA
    FERSINI, G
    NISTICO, G
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (03) : 1802 - 1806