AGE-DEPENDENT CHANGES OF NO SYNTHASE ACTIVITY IN THE RAT-BRAIN

被引：49

作者：

MOLLACE, V ^{[1
]}

RODINO, P ^{[1
]}

MASSOUD, R ^{[1
]}

ROTIROTI, D ^{[1
]}

NISTICO, G ^{[1
]}

机构：

[1] UNIV REGGIO CALABRIA,FAC PHARM,CNR,IBAF CTR,CATANZARO,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.2537

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report that NO synthase activity, as expressed by citrulline and nitrite formation in brain homogenates, is decreased in 24-month old in comparison to 3-month old rats. In particular, a Ca++-dependent NO synthase activity was detected in homogenates obtained from cortical, hippocampal, cerebellar and lower brain stem slices from both 3- and 24 month - old rats. The amount of citrulline generated from L-arginine was significantly decreased in the hippocampus and lower brain stem by 40 and 48%, respectively. No changes were observed in NO synthase activity in cortical and cerebellar homogenates. Thus, the L-arginine-NO pathway seems to be impaired in selected areas of rat brain and this may contribute to the understanding of pathophysiological mechanisms underlying age-related cerebral disorders. (C) 1995 Academic Press. Inc.

引用

页码：822 / 827

页数：6

共 15 条

[11] EVIDENCE THAT L-ARGININE POSSESSES PROCONVULSANT EFFECTS MEDIATED THROUGH NITRIC-OXIDE
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[12] AGE-RELATED ALTERATIONS IN CARDIOVASCULAR RESPONSIVENESS TO CLONIDINE INFUSED INTO THE NUCLEUS TRACTUS SOLITARII IN RATS
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[13] EVIDENCE THAT PHARMACOLOGICAL MANIPULATIONS OF CENTRAL L-ARGININE-NO PATHWAY INFLUENCE BLOOD-PRESSURE AND HEART-RATE IN RATS
MOLLACE, V
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[14] MOLLACE V, 1992, BIOL NITRIC OXIDE, P169
[15] MONCADA S, 1991, PHARMACOL REV, V43, P109

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