DETERMINATION OF THE MINIMUM ALVEOLAR CONCENTRATION (MAC) OF ALIFLURANE IN DOGS

被引：2

作者：

MUNSON, ES

SCHICK, LM

CHAPIN, JC

KUSHINS, LG

NAVARRO, AA

机构：

来源：

ANESTHESIOLOGY | 1979年 / 51卷 / 06期

关键词：

D O I：

10.1097/00000542-197912000-00013

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

The minimum alveolar concentration (MAC) of aliflurane was measured in ten dogs. A value of 1.84 volumes per cent was determined, which correlates well with predictions based on lipid solubility. Induction of anesthesia and recovery were rapid, as would be anticipated with an agent of relatively low solubility in blood (blood-gas partition coefficient = 1.7). Circulatory responses over a relatively narrow range of aliflurane concentrations (0.8 to 1.4 MAC) remained stable, but the development of tachypnea, irregular ventilatory patterns, and increased muscle tone were frequently encountered during aliflurane anesthesia.

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页码：545 / 547

页数：3

相关论文

共 12 条

[1] EQUIPOTENT ALVEOLAR CONCENTRATIONS OF METHOXYFLURANE HALOTHANE DIETHYL ETHER FLUOROXENE CYCLOPROPANE XENON AND NITROUS OXIDE IN DOG [J].

EGER, EI ;

BRANDSTATER, B ;

SAIDMAN, LJ ;

REGAN, MJ ;

SEVERINGHAUS, JW ;

MUNSON, ES .

ANESTHESIOLOGY, 1965, 26 (6P1) :771-+

[2]

EGER EI, 1969, ANESTHESIOLOGY, V30, P129

[3] ANAESTHETIC SOLUBILITY IN BLOOD + TISSUES - VALUES + SIGNIFICANCE [J].

EGER, EI ;

LARSON, CP .

BRITISH JOURNAL OF ANAESTHESIA, 1964, 36 (03) :140-+

[4] MINIMUM ALVEOLAR ANESTHETIC CONCENTRATION - A STANDARD OF ANESTHETIC POTENCY [J].

EGER, EI ;

SAIDMAN, LJ ;

BRANDSTATER, B .

ANESTHESIOLOGY, 1965, 26 (6P1) :756-+

[5] MINIMUM ALVEOLAR CONCENTRATION OF ENFLURANE IN MAN [J].

GION, H ;

SAIDMAN, LJ .

ANESTHESIOLOGY, 1971, 35 (04) :361-&

[6] UPTAKE AND BIOTRANSFORMATION OF ALIFLURANE (1-CHLORO-2-METHOXY-1,2,3,3-TETRAFLUOROCYCLO-PROPANE, COMPOUND 26-P) IN MAN [J].

HOLADAY, DA ;

JARDINES, MC ;

GREENWOOD, WH .

ANESTHESIOLOGY, 1979, 51 (06) :548-550

[7] EFFECT OF NITROUS OXIDE AND MORPHINE ON MINIMUM ANESTHETIC CONCENTRATION OF FLUROXENE [J].

MUNSON, ES ;

SAIDMAN, LJ ;

EGER, EI .

ANESTHESIOLOGY, 1965, 26 (02) :134-+

[8] PROGRAM FOR CALCULATION OF INTRAPULMONARY SHUNTS, BLOOD-GAS AND ACID-BASE VALUES WITH A PROGRAMMABLE CALCULATOR [J].

RUIZ, BC ;

TUCKER, WK ;

KIRBY, RR .

ANESTHESIOLOGY, 1975, 42 (01) :88-95

[9] EFFECT OF NITROUS OXIDE + OF NARCOTIC PREMEDICATION ON ALVEOLAR CONCENTRATION OF HALOTHANE REQUIRED FOR ANESTHESIA [J].

SAIDMAN, LJ ;

EGER, EI .

ANESTHESIOLOGY, 1964, 25 (03) :302-&

[10] MINIMUM ALVEOLAR CONCENTRATIONS OF METHOXYFLURANE HALOTHANE ETHER AND CYCLOPROPANE IN MAN - CORRELATION WITH THEORIES OF ANESTHESIA [J].

SAIDMAN, LJ ;

EGER, EI ;

MUNSON, ES ;

BABAD, AA ;

MUALLEM, M .

ANESTHESIOLOGY, 1967, 28 (6P1) :994-+