COMPLEMENT ALLOTYPES IN JAPANESE PATIENTS WITH PEMPHIGUS AND BULLOUS PEMPHIGOID

被引：2

作者：

NISHIMUKAI, H ^{[1
]}

SHIRAISHI, S ^{[1
]}

SHIRAKATA, Y ^{[1
]}

SAYAMA, K ^{[1
]}

SHINOMIYA, T ^{[1
]}

MIKI, Y ^{[1
]}

机构：

[1] EHIME UNIV,SCH MED,DEPT DERMATOL,SHIGENOBU,EHIME 79102,JAPAN

来源：

DERMATOLOGICA | 1991年 / 182卷 / 03期

关键词：

PEMPHIGUS; BULLOUS PEMPHIGOID; COMPLEMENT; ALLOTYPE;

D O I：

10.1159/000247770

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The allotypes of C6, C7, factor B (BF) and factor I (IF) of the human complement system were studied in 11 Japanese patients with pemphigus (5 with pemphigus vulgaris and 6 with pemphigus foliaceus) and 17 with bullous pemphigoid (BP) to investigated the genetic background of these diseases. The allotypes were detected by using isoelectric focusing and immunoblotting. The frequency for IF*A allele in the pemphigus patients was significantly higher (p = 0.009) than that in healthy controls (n = 60). A significant association of IF A allotype with pemphigus was also observed (p = 0.027), with a relative risk of 6.3. There was no association between the C6, C7, BF or IF allotypes and BP. These data suggest that IF A allotype may be an etiological genetic factor in the development of pemphigus.

引用

页码：164 / 167

页数：4

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