AN EFFICIENT SYNTHESIS OF R3SI(CH2)N-SUBSTITUTED ACETYLACETONE DERIVATIVES

An efficient synthesis of R3Si(CH2)3CH[C(O)Me]2 3 [R = Me, OR') is described. The reaction of R3Si(CH2)3Cl 2 with the sodium or potassium salt of acetylacetonate (1) and 0.8-2 equivalents of NaI or KI in DMF, DMSO or NMP as a solvent gives the C- and O-alkylation products R3Si(CH2)3CH[C(O)Me]2 3 and R3Si(CH2)3OC(Me) = CH - C(O)Me 4 in a 3:1 ratio and a 60 - 70% total yield. For R3SiCH2CH[C(O)Me]2 selectivity and yields are lower.