CELLULAR COLOCALIZATION OF CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE-II AND CALCINEURIN IN THE RAT CEREBRAL-CORTEX AND HIPPOCAMPUS

被引：24

作者：

GOTO, S

NAGAHIRO, S

KOREMATSU, K

USHIO, Y

FUKUNAGA, K

MIYAMOTO, E

HOFER, W

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT PHARMACOL,KUMAMOTO 860,JAPAN

[2] MAX PLANCK INST BRAIN RES,ELECTRON MICROSCOPY LAB,W-6000 FRANKFURT,GERMANY

来源：

NEUROSCIENCE LETTERS | 1993年 / 149卷 / 02期

关键词：

CALCINEURIN; TYPE-II CA2+ CALMODULIN-DEPENDENT PROTEIN KINASE; IMMUNOCYTOCHEMISTRY; CEREBRAL CORTEX; HIPPOCAMPUS;

D O I：

10.1016/0304-3940(93)90768-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An immunoperoxidase technique was used to locate multifunctional Ca2+/calmodulin-regulated protein phosphatase (calcineurin) and kinase (CaM-kinase II) in the rat cerebral cortex and hippocampus. Immunoreactivities for both enzymes were highly concentrated in the brain regions, where pyramidal-shaped neurons revealed strong immunoreactivities in their perikarya and dendrites. Serial thin section analysis using the polyethylene glycol embedding procedure disclosed that the cellular distribution of calcineurin immunolabelling in the cerebral cortex and hippocampus was similar to that of CaM-kinase II. The present findings suggest that the phosphatase and kinase may interact with each other in such neuronal subsets.

引用

页码：189 / 192

页数：4

共 25 条

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