THE UNUSUAL STRUCTURE OF THE HUMAN CENTROMERE (GGA)(2) MOTIF - UNPAIRED GUANOSINE RESIDUES STACKED BETWEEN SHEARED G-CENTER-DOT-A PAIRS

被引：56

作者：

CHOU, SH ^{[1
]}

ZHU, LM ^{[1
]}

REID, BR ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT CHEM, SEATTLE, WA 98195 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1994年 / 244卷 / 03期

关键词：

SHEARED G-CENTER-DOT-A PAIRS; UNPAIRED G-STACKS; NMR; CENTROMERE; DNA REPEAT;

D O I：

10.1006/jmbi.1994.1727

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The centromere of human chromosomes contains multiple repeats of the DNA sequence d(TGGAA)(n). This sequence has the interesting property of pairing with itself to form stable duplexes. We have determined the solution structure of the unusual DNA duplex 5'-TGGAATGGAA:TGGAATGGAA-3' at atomic resolution. The duplex contains unpaired staggered guanosine residues, which co-stack by intercalation between sheared G(.)A and A(.)G base-pairs to form an interesting new structural motif. the GA-bracketed G-stack. The TGGAA repeat unit contains six ''steps'', four of which are not Watson-Crick base-pairs.

引用

页码：259 / 268

页数：10

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