Synthesis and coupling reactions of alpha,alpha-dialkylated amino acids with nucleobase side chains

被引：4

作者：

Azumaya, I

Aebi, R

Kubik, S

Rebek, J

机构：

[1] Department of Chemistry, Massachusetts Inst. of Technology, Cambridge

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 26期

关键词：

D O I：

10.1073/pnas.92.26.12013

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several di- and tripeptides containing protected purine (adenine) and pyrimidine (thymine) residues on their side chains were synthesized. The parent amino acids are alpha,alpha-dialkylated in a symmetrical manner. An effective coupling procedure was developed for these sterically hindered amino acids: the fluoren-9-ylmethyloxycarbonyl-protected amino acid was dehydrated to its oxazolinone form, which was coupled in good yields with amino esters in hot tetrachloroethane.

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页码：12013 / 12016

页数：4

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