URINARY EXCRETION OF BETA-HYDROXYBUTYRATE AND ACETOACETATE DURING EXPERIMENTAL KETOSIS

被引：20

作者：

GALVIN, RD

HARRIS, JA

JOHNSON, RE

机构：

[1] Human Environmental Research Unit, Department of Physiology and Biophysics, University of Illinois, Urbana, Illinois

来源：

QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES | 1968年 / 53卷 / 02期

关键词：

D O I：

10.1113/expphysiol.1968.sp001958

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Acetoacetate and beta‐hydroxybutyrate in blood and urine have been studied in experimental ketosis produced in healthy young men and women by: (a) exercise in the post‐absorptive state, (b) starvation and exercise, or (c) a high‐fat, low‐carbohydrate diet. With an increasing severity of ketosis, the plot of rate of excretion of acetoacetate against its concentration in the blood was a straight line, whereas the plot of the rate of excretion of beta‐hydroxybutyrate against its concentration in the blood was exponential. The two ketone bodies had a constant ratio in the plasma, but, as ketosis progressed, beta‐hydroxybutyrate became the preponderant molecule in the urine. The renal clearances of both acetoacetate and beta‐hydroxybutyrate were much lower than that for creatinine. © 1968 The Physiological Society

引用

页码：181 / +

页数：1