学术探索
学术期刊
新闻热点
数据分析
智能评审
立即登录
AN HLA-ASSOCIATED NONRESPONSIVENESS TO MELITTIN - A COMPONENT OF BEE VENOM
被引:38
作者
:
LYMPANY, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND
LYMPANY, P
KEMENY, DM
论文数:
0
引用数:
0
h-index:
0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND
KEMENY, DM
WELSH, KI
论文数:
0
引用数:
0
h-index:
0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND
WELSH, KI
LEE, TH
论文数:
0
引用数:
0
h-index:
0
机构:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND
LEE, TH
机构
:
[1]
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ALLERGY & ALLIED RESP DISORDERS,LONDON SE1 9RT,ENGLAND
[2]
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT TISSUE TYPING,LONDON SE1 9RT,ENGLAND
来源
:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
|
1990年
/ 86卷
/ 02期
关键词
:
D O I
:
10.1016/S0091-6749(05)80061-2
中图分类号
:
R392 [医学免疫学];
学科分类号
:
100102 ;
摘要
:
Previous work has demonstrated a close association between certain histocompatibility antigens and the gene that controls the IgE response to certain ragweed allergens. For example, there is a 90% association between IgE production to the short ragweed allergen, Amb a V, and an HLA class II allele. To assess whether these HLA linkages are specific for ragweed, we have investigated the association between HLA antigens and the capacity of individuals to mount a specific IgE response to melittin in patients with bee-venom allergy. Twenty-two subjects with bee-venom sensitivity, 22 healthy beekeepers without bee-venom allergy, and a normal population of 149 unselected individuals were studied. With serologic tissue typing and restriction fragment length polymorphism analysis, we have demonstrated a significant decrease in the HLA-DR4 and DQw3 alleles in subjects who are allergic to melittin compared to the control populations. There was also a negative association between the presence of HLA-DR4 and DQw3 alleles with the capacity of the individuals to mount an IgE response to phospholipase A2 (PLA2). The bee-venom sensitive subjects had a slightly lower titer of anti-PLA2 IgG when these subjects were compared to the bee-venom insensitive beekeepers. These results support the view that either HLA-DR or HLA-DQ has a protective role in controlling the IgE immune response. Lack of an IgE response to melittin or PLA2 is unlikely to be due to a failure to recognize allergen. © 1990 Mosby-Year Book, Inc.
引用
收藏
页码:160 / 170
页数:11
相关论文
共 36 条
[31]
BOTH ALPHA-CHAINS AND BETA-CHAINS OF HLA-DC CLASS-II HISTOCOMPATIBILITY ANTIGENS DISPLAY EXTENSIVE POLYMORPHISM IN THEIR AMINO-TERMINAL DOMAINS
SCHENNING, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
SCHENNING, L
LARHAMMAR, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
LARHAMMAR, D
BILL, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
BILL, P
WIMAN, K
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
WIMAN, K
JONSSON, AK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
JONSSON, AK
RASK, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
RASK, L
PETERSON, PA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
PETERSON, PA
[J].
EMBO JOURNAL,
1984,
3
(02)
: 447
-
452
[32]
PREVALENCE OF BEE STING ALLERGY IN 4,992 BOY SCOUTS
SETTIPANE, GA
论文数:
0
引用数:
0
h-index:
0
SETTIPANE, GA
BOYD, GK
论文数:
0
引用数:
0
h-index:
0
BOYD, GK
[J].
ACTA ALLERGOLOGICA,
1970,
25
(04):
: 286
-
+
[33]
ALLERGY TO INSECT STINGS .1. DIAGNOSIS OF LGE-MEDIATED HYMENOPTERA SENSITIVITY BY VENOM-INDUCED HISTAMINE-RELEASE
SOBOTKA, AK
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
SOBOTKA, AK
VALENTINE, MD
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
VALENTINE, MD
BENTON, AW
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
BENTON, AW
LICHTENSTEIN, LM
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
LICHTENSTEIN, LM
[J].
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
1974,
53
(03)
: 170
-
184
[34]
DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS
SOUTHERN, EM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV EDINBURGH, DEPT ZOOL, MRC MAMMALIAN GENOME UNIT, W MAINS RD, EDINBURGH, SCOTLAND
UNIV EDINBURGH, DEPT ZOOL, MRC MAMMALIAN GENOME UNIT, W MAINS RD, EDINBURGH, SCOTLAND
SOUTHERN, EM
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1975,
98
(03)
: 503
-
+
[35]
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS
TERASAKI, PI
论文数:
0
引用数:
0
h-index:
0
TERASAKI, PI
MCCLELLAND, JD
论文数:
0
引用数:
0
h-index:
0
MCCLELLAND, JD
[J].
NATURE,
1964,
204
(496)
: 998
-
&
[36]
TROWSDALE J, 1975, IMMUNOL REV, V85, P5
←
1
2
3
4
→
共 36 条
[31]
BOTH ALPHA-CHAINS AND BETA-CHAINS OF HLA-DC CLASS-II HISTOCOMPATIBILITY ANTIGENS DISPLAY EXTENSIVE POLYMORPHISM IN THEIR AMINO-TERMINAL DOMAINS
SCHENNING, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
SCHENNING, L
LARHAMMAR, D
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
LARHAMMAR, D
BILL, P
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
BILL, P
WIMAN, K
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
WIMAN, K
JONSSON, AK
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
JONSSON, AK
RASK, L
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
RASK, L
PETERSON, PA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV UPPSALA,WALLENBERG LAB,DEPT CELL RES,S-75122 UPPSALA,SWEDEN
PETERSON, PA
[J].
EMBO JOURNAL,
1984,
3
(02)
: 447
-
452
[32]
PREVALENCE OF BEE STING ALLERGY IN 4,992 BOY SCOUTS
SETTIPANE, GA
论文数:
0
引用数:
0
h-index:
0
SETTIPANE, GA
BOYD, GK
论文数:
0
引用数:
0
h-index:
0
BOYD, GK
[J].
ACTA ALLERGOLOGICA,
1970,
25
(04):
: 286
-
+
[33]
ALLERGY TO INSECT STINGS .1. DIAGNOSIS OF LGE-MEDIATED HYMENOPTERA SENSITIVITY BY VENOM-INDUCED HISTAMINE-RELEASE
SOBOTKA, AK
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
SOBOTKA, AK
VALENTINE, MD
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
VALENTINE, MD
BENTON, AW
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
BENTON, AW
LICHTENSTEIN, LM
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED, BALTIMORE, MD USA
LICHTENSTEIN, LM
[J].
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY,
1974,
53
(03)
: 170
-
184
[34]
DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS
SOUTHERN, EM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV EDINBURGH, DEPT ZOOL, MRC MAMMALIAN GENOME UNIT, W MAINS RD, EDINBURGH, SCOTLAND
UNIV EDINBURGH, DEPT ZOOL, MRC MAMMALIAN GENOME UNIT, W MAINS RD, EDINBURGH, SCOTLAND
SOUTHERN, EM
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1975,
98
(03)
: 503
-
+
[35]
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS
TERASAKI, PI
论文数:
0
引用数:
0
h-index:
0
TERASAKI, PI
MCCLELLAND, JD
论文数:
0
引用数:
0
h-index:
0
MCCLELLAND, JD
[J].
NATURE,
1964,
204
(496)
: 998
-
&
[36]
TROWSDALE J, 1975, IMMUNOL REV, V85, P5
←
1
2
3
4
→