CYTOGENETIC STUDY OF PERSONS OCCUPATIONALLY EXPOSED TO ETHYLENE-OXIDE

被引：15

作者：

LERDA, D ^{[1
]}

RIZZI, R ^{[1
]}

机构：

[1] DEPT PHARMACOL, CHAIR TOXICOL, MILAN, ITALY

来源：

MUTATION RESEARCH | 1992年 / 281卷 / 01期

关键词：

HUMAN MONITORING; ETHYLENE OXIDE EXPOSURE; SISTER-CHROMATID EXCHANGE; CHROMOSOMAL ABERRATIONS; PERIPHERAL LYMPHOCYTES; BLOOD CHEMISTRY PARAMETERS;

D O I：

10.1016/0165-7992(92)90033-E

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ten persons occupationally exposed to ethylene oxide (EO), used in the sterilization of medical instruments, were studied at a hospital. The estimated concentration to which they were exposed was 60-69 ppm, TWA. Peripheral blood samples from 10 workers and 10 controls of the same age and sex were taken to determine the frequency of sister-chromatid exchanges (SCE) and chromosomal aberrations (CA). The mean frequencies of SCE/cell (X = S) were 13.27 for the exposed workers and 6.05 for controls. Chromosome aberration frequencies in exposed individuals were significantly increased compared with controls. A significant relationship between the frequencies of SCE and CA and EO exposure was demonstrated. Blood chemistry parameters such as urea, creatinine, uric acid, lactic dehydrogenase, glutamic oxaloacetic and pyruvic transaminases, luteinizing gonadotropin and follicle stimulating gonadotropin and thyrotropin were also measured and found to be within the normal range.

引用

页码：31 / 37

页数：7

共 28 条

[21] SISTER-CHROMATID EXCHANGES IN ASSOCIATION WITH OCCUPATIONAL EXPOSURE TO ETHYLENE-OXIDE [J].

STOLLEY, PD ;

SOPER, KA ;

GALLOWAY, SM ;

NICHOLS, WW ;

NORMAN, SA ;

WOLMAN, SR .

MUTATION RESEARCH, 1984, 129 (01) :89-102

[22]

WOLFF S, 1985, SISTER CHROMATID EXC, P41

[23] EXPOSURE TO ETHYLENE-OXIDE AT WORK INCREASES SISTER CHROMATID EXCHANGES IN HUMAN PERIPHERAL LYMPHOCYTES [J].

YAGER, JW ;

HINES, CJ ;

SPEAR, RC .

SCIENCE, 1983, 219 (4589) :1221-1223

[24]

1983, 47 MIN DELL SAN MOD

[25]

1986, THRESHOLD LIMIT VALU

[26]

1983, 24 MONTHS SISTER CHR

[27]

1977, MANUAL ANAL METHODS, V3

[28]

1985, EVALUATION CARCINOGE, V36, P189

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