MICROBIAL STRATEGIES TO PREVENT OXYGEN-DEPENDENT KILLING BY PHAGOCYTES

被引：54

作者：

HAAS, A ^{[1
]}

GOEBEL, W ^{[1
]}

机构：

[1] UNIV WURZBURG, INST GENET & MICROBIOL, W-8700 WURZBURG, GERMANY

来源：

FREE RADICAL RESEARCH COMMUNICATIONS | 1992年 / 16卷 / 03期

关键词：

PHAGOCYTES; PATHOGENICITY; INTRACELLULAR LIFE-STYLE; SUPEROXIDE DISMUTASE; CATALASE; REACTIVE OXYGEN SPECIES;

D O I：

10.3109/10715769209049167

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microorganisms which are taken up by professional phagocytic cells of a host organism (e.g., by macrophages and polymorphonuclear leukocytes) encounter a series of antimicrobial events including confrontation with toxic oxygen species, derived mainly from the superoxide radical produced by phagocytic NADPH oxidase after uptake of the microorganism. Many microbes are susceptible to the oxygen-dependent phagocytic stress and are efficiently killed. The strategies of some microorganisms to bypass an encounter with the phagocytes' reactive oxygen species, and biochemical systems contributing to the microbes' resistance to killing by reactive oxygen species are outlined. © 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：137 / 157

页数：21

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