CONSERVATION OF A VARIANT-SPECIFIC SURFACE-ANTIGEN GENE IN DIFFERENT TRYPANOSOME SPECIES AND SUBSPECIES

被引：21

作者：

PAYS, E ^{[1
]}

LHEUREUX, M ^{[1
]}

VERVOORT, T ^{[1
]}

STEINERT, M ^{[1
]}

机构：

[1] INST TROP GENEESKUNDE, SEROL LAB, B-2000 ANTWERP, BELGIUM

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1981年 / 4卷 / 5-6期

关键词：

D O I：

10.1016/0166-6851(81)90066-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Trypanosoma brucei brucei, T. b. rhodesiense, T. b. gambiense and T. evansi, the variant-specific antigen (VSA) genes are organized in families of related sequences, one of which is duplicated when expressed. Some of these VSA sequences appear to be conserved in the different species and sub-species: restriction mapping of isotypic genes of AnTat 1.8 VSA (from T. b. brucei) reveals extensive homology in T. b. rhodesiense, T. b. gambiense and T. evansi, although the genetic surrounding differs in each case. The AnTat 1.1 sequence (also from T. b. brucei) appears to be absent from T. b. gambiense DNA.

引用

页码：349 / 357

页数：9

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